First Description of Azole-Resistant Aspergillus fumigatus Due to TR46/Y121F/T289A Mutation in France

被引：54

作者：

Lavergne, Rose-Anne ^{[1
,2
]}

Morio, Florent ^{[1
,2
]}

Favennec, Loic ^{[3
,4
]}

Dominique, Stephane ^{[5
]}

Meis, Jacques F. ^{[6
,7
]}

Gargala, Gilles ^{[3
,4
]}

Verweij, Paul E. ^{[7
]}

Le Pape, Patrice ^{[1
,2
]}

机构：

[1] Nantes Atlantique Univ, Univ Nantes, Dept Parasitol & Mycol Med, IICIMed EA1155,Fac Pharm, Nantes, France

[2] CHU Nantes, Inst Biol, Lab Parasitol Mycol, Nantes, France

[3] Univ Rouen, Lab Parasitol Mycol, EA3800, Rouen, France

[4] CHU Rouen, Rouen, France

[5] Rouen Univ Hosp, Cyst Fibrosis Ctr, Dept Pneumol, Rouen, France

[6] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[7] Radford Univ, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 07期

关键词：

CYSTIC-FIBROSIS; FRENCH COHORT; PREVALENCE; ENVIRONMENT; BELGIUM;

D O I：

10.1128/AAC.00127-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.

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页码：4331 / 4335

页数：5

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