Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

被引：1

作者：

Kovalchuka, Lilija ^{[1
]}

Cvetkova, Svetlana ^{[1
]}

Trofimova, Julija ^{[1
]}

Eglite, Jelena ^{[2
]}

Gintere, Sandra ^{[3
]}

Lucenko, Irina ^{[4
]}

Oczko-Grzesik, Barbara ^{[5
]}

Viksna, Ludmila ^{[6
]}

Krumina, Angelika ^{[1
,6
]}

机构：

[1] Inst Food Safety Anim Hlth & Environm BIOR, LV-1076 Riga, Latvia

[2] Riga Stradins Univ, Lab Clin Immunol & Immunogenet, LV-1067 Riga, Latvia

[3] Riga Stradins Univ, Dept Family Med, LV-1067 Riga, Latvia

[4] Ctr Dis Prevent & Control Latvia, LV-1005 Riga, Latvia

[5] Med Univ Silesia, Dept Infect Dis, PL-40055 Katowice, Poland

[6] Riga Stradins Univ, Dept Infectol & Dermatol, LV-1006 Riga, Latvia

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2016年 / 13卷 / 12期

关键词：

Borrelia burgdorferi; Lyme borreliosis; Lyme neuroborreliosis; immunogenetic markers; HLA-DRB1; IXODES-RICINUS TICKS; BURGDORFERI SENSU-LATO; HLA-DR; GEOGRAPHICAL-DISTRIBUTION; BORNE PATHOGENS; QUESTING TICKS; DISEASE; INFECTION; ASSOCIATIONS; MOLECULES;

D O I：

10.3390/ijerph13121194

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

引用

页数：11

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