Microneedle Patches Loaded with Nanovesicles for Glucose Transporter- Mediated Insulin Delivery

被引：54

作者：

Chen, Qian ^{[1
,2
,3
,4
,5
]}

Xiao, Zhisheng ^{[1
]}

Wang, Chao ^{[1
,2
,3
]}

Chen, Guojun ^{[2
,3
,5
]}

Zhang, Yuqi ^{[2
,3
,4
,5
,6
]}

Zhang, Xudong ^{[2
,3
,4
,5
]}

Han, Xiao ^{[4
]}

Wang, Jinqiang ^{[2
,3
,4
,5
,6
]}

Ye, Xiao ^{[8
,9
]}

Prausnitz, Mark R. ^{[7
]}

Li, Song ^{[4
]}

Gu, Zhen ^{[2
,3
,5
,6
,10
,11
,12
,13
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[2] Univ North Carolina Chapel Hill, North Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27695 USA

[3] North Carolina State Univ, Raleigh, NC 27695 USA

[4] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA

[6] Zhejiang Univ, Coll Pharmaceut Sci, Key Lab Adv Drug Delivery Syst Zhejiang Prov, Hangzhou 310058, Peoples R China

[7] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

[8] Key Lab Diag & Treatment Endocrine Gland Dis Zheji, Hangzhou 310014, Zhejiang, Peoples R China

[9] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Hangzhou Med Coll, Geriatr Med Ctr, Hangzhou 310014, Zhejiang, Peoples R China

[10] Zhejiang Univ, Jinhua Inst, Jinhua 321299, Peoples R China

[11] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Surg, Hangzhou 310016, Peoples R China

[12] Zhejiang Univ Med Ctr, Zhejiang Lab Syst & Precis Med, Hangzhou 311121, Peoples R China

[13] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

来源：

ACS NANO | 2022年 / 16卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

drug delivery; glucose transporter; microneedles; diabetes; glucose-responsive; RESPONSIVE RELEASE; THERAPY; COMPLICATIONS; NANOPARTICLES; VACCINATION; GEL;

D O I：

10.1021/acsnano.2c05687

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glucose-responsive insulin delivery systems that mimic insulin secretion activity in the pancreas show great potential to improve clinical therapeutic outcomes for people with type 1 and advanced type 2 diabetes. Here, we report a glucose-responsive insulin delivery microneedle (MN) array patch that is loaded with red blood cell (RBC) vesicles or liposome nanoparticles containing glucose transporters (GLUTs) bound with glucosamine-modified insulin (GluInsulin). In hyperglycemic conditions, high concentrations of glucose in interstitial fluid can replace Glu-Insulin via a competitive interaction with GLUT, leading to a quick release of Glu-Insulin and subsequent regulation of blood glucose (BG) levels in vivo. To prolong the effective glucose-responsive insulin release from MNs, additional free Glu-Insulin, which serves as "stored insulin", is loaded after RBC vesicles or liposome nanoparticles bound with Glu-Insulin. In the streptozotocin (STZ)-induced type 1 diabetic mouse model, this smart GLUT-based insulin patch can effectively control BG levels without causing hypoglycemia.

引用

页码：18223 / 18231

页数：9

共 45 条

[1] Current Diabetes Technology: Striving for the Artificial Pancreas [J].

Allen, Natalie ;

Gupta, Anshu .

DIAGNOSTICS, 2019, 9 (01)

[2] Materials for Diabetes Therapeutics [J].

Bratlie, Kaitlin M. ;

York, Roger L. ;

Invernale, Michael A. ;

Langer, Robert ;

Anderson, Daniel G. .

ADVANCED HEALTHCARE MATERIALS, 2012, 1 (03) :267-284

[3]

Chen Guojun, 2019, J Diabetes Sci Technol, V13, P41, DOI 10.1177/1932296818778607

[4]

Chen ZW, 2018, NAT CHEM BIOL, V14, P86, DOI [10.1038/NCHEMBIO.2511, 10.1038/nchembio.2511]

[5] Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates [J].

Chou, Danny Hung-Chieh ;

Webber, Matthew J. ;

Tang, Benjamin C. ;

Lin, Amy B. ;

Thapa, Lavanya S. ;

Deng, David ;

Truong, Jonathan V. ;

Cortinas, Abel B. ;

Langer, Robert ;

Anderson, Daniel G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (08) :2401-2406

[6] Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation [J].

Dong, Yizhou ;

Wang, Weiheng ;

Veiseh, Omid ;

Appel, Eric A. ;

Xue, Kun ;

Webber, Matthew J. ;

Tang, Benjamin C. ;

Yang, Xi-Wen ;

Weir, Gordon C. ;

Langer, Robert ;

Anderson, Daniel G. .

LANGMUIR, 2016, 32 (34) :8743-8747

[7] Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery [J].

Fang, Ronnie H. ;

Hu, Che-Ming J. ;

Luk, Brian T. ;

Gao, Weiwei ;

Copp, Jonathan A. ;

Tai, Yiyin ;

O'Connor, Derek E. ;

Zhang, Liangfang .

NANO LETTERS, 2014, 14 (04) :2181-2188

[8] Controlled release of biologics for the treatment of type 2 diabetes [J].

Gilroy, Caslin A. ;

Luginbuhl, Kelli M. ;

Chilkoti, Ashutosh .

JOURNAL OF CONTROLLED RELEASE, 2016, 240 :151-164

[9] Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery [J].

Gu, Zhen ;

Dang, Tram T. ;

Ma, Minglin ;

Tang, Benjamin C. ;

Cheng, Hao ;

Jiang, Shan ;

Dong, Yizhou ;

Zhang, Yunlong ;

Anderson, Daniel G. .

ACS NANO, 2013, 7 (08) :6758-6766

[10] Injectable Nano-Network for Glucose-Mediated Insulin Delivery [J].

Gu, Zhen ;

Aimetti, Alex A. ;

Wang, Qun ;

Dang, Tram T. ;

Zhang, Yunlong ;

Veiseh, Omid ;

Cheng, Hao ;

Langer, Robert S. ;

Anderson, Daniel G. .

ACS NANO, 2013, 7 (05) :4194-4201

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