The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice

被引：25
作者：
Salla, Juliana Tito [1 ]
de Albuquerque Taddei, Silvana Rodrigues [1 ,2 ]
Queiroz-Junior, Celso Martins [1 ,2 ]
Junior, Ildeu Andrade [2 ,3 ]
Teixeira, Mauro Martins [2 ]
Silva, Tarcilia Aparecida [1 ,2 ]
机构：
[1] Univ Fed Minas Gerais, Fac Odontol, Dept Oral Surg & Pathol, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biochem & Immunol, Lab Immunopharmacol, Belo Horizonte, MG, Brazil
[3] Pontificia Univ Catol Minas Gerais PUG Minas, Fac Dent, Dept Orthodont, Belo Horizonte, MG, Brazil
来源：
ARCHIVES OF ORAL BIOLOGY | 2012年 / 57卷 / 05期
关键词：
Interleukin-1 receptor antagonist (IL-1Ra); Interleukin-1 (IL-1); Mechanical loading; Orthodontic tooth movement; GINGIVAL CREVICULAR FLUID; PERIODONTAL-LIGAMENT; GENE POLYMORPHISMS; EXPRESSION; CYTOKINES; MECHANISMS; SECRETION; ARTHRITIS; FORCE; CELLS;
D O I：
10.1016/j.archoralbio.2011.09.018
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective: Orthodontic tooth movement (OTM) is achieved by alveolar bone remodelling induced by mechanical loading. Whilst interleukin-1 (IL-1) is directly involved in OTM, the role of interleukin-1 receptor antagonist (IL-1Ra), a naturally occurring IL-1 antagonist, is not completely defined. Therefore, the aim of this study was to investigate the effects of IL-1Ra on OTM. Methods: An orthodontic appliance was placed in C57BL6 mice treated with vehicle or IL-1Ra (10 mg/kg/day). OTM and TRAP-positive osteoclasts were evaluated after 12 days of mechanical loading and the levels of cytokines on periodontal tissues were analysed by ELISA after 12 and 72 h. Results: Mice treated with IL-1Ra showed diminished OTM and decreased numbers of TRAP-positive osteoclasts. In line with this, lower levels of IL-1 beta and TNF-alpha, and higher levels of IL-10, were observed on periodontal tissues of IL-1Ra-treated mice in relation to the vehicle-treated group. Conclusion: The present study suggests that IL-1Ra downregulates OTM, probably by its anti-inflammatory actions. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：519 / 524
页数：6
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