Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity

被引：5
|
作者：
Roy, Sreeja [1 ]
Williams, Clare M. [1 ]
Pardo, Julian [2 ]
Wijesundara, Danushka K. [3 ]
Furuya, Yoichi [1 ]
机构：
[1] Albany Med Coll, Dept Immunol & Microbial Dis, Albany, NY 12208 USA
[2] Biomed Res Ctr Aragon, Aragon Hlth Res Inst, Immunotherapy Inflammat & Canc, Zaragoza 50009, Spain
[3] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia
来源：
VACCINES | 2020年 / 8卷 / 03期
基金：
美国国家卫生研究院;
关键词：
influenza; pre-existing immunity; live attenuated influenza vaccine; inactivated influenza vaccine; UNITED-STATES; EFFICACY; SAFETY; VIRUS; RECOMMENDATIONS; MICE;
D O I：
10.3390/vaccines8030459
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The efficacy of the intranasally (i.n.) delivered live attenuated influenza vaccine (LAIV) is variable and, in some seasons, suboptimal. In this study, we report that LAIV exhibits cross-protective efficacy in mice, potentially associated with cellular immunity as opposed to antigen-specific antibody responses. However, pre-exposure to the intramuscularly (i.m.) delivered inactivated influenza vaccine (IIV) severely impaired LAIV-induced cross-protection against heterologous challenge, potentially by inhibiting replication of LAIV. Our findings suggest that pre-existing immunity afforded by IIV suppresses cross-protective T cell immunogenicity of LAIV.
引用
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页码：1 / 6
页数：6
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