MALDI-TOF MS: an upcoming tool for rapid detection of antibiotic resistance in microorganisms

被引：100
作者：
Kostrzewa, Markus [1 ]
Sparbier, Katrin [1 ]
Maier, Thomas [1 ]
Schubert, Soeren [2 ]
机构：
[1] Bruker Daltonik GmbH, Bremen, Germany
[2] Max Von Pettenkofer Inst, Munich, Germany
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2013年 / 7卷 / 11-12期
关键词：
Clinical microbiology; Diagnostic; MALDI-TOF MS; Resistance detection; DESORPTION IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; ASSISTED-LASER-DESORPTION/IONIZATION; STAPHYLOCOCCUS-AUREUS STRAINS; POSITIVE BLOOD CULTURES; METHICILLIN-RESISTANT; DIRECT IDENTIFICATION; SPECIES IDENTIFICATION; ROUTINE IDENTIFICATION; ANAEROBIC-BACTERIA;
D O I：
10.1002/prca.201300042
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
MALDI-TOF MS profiling for microorganism detection has already been demonstrated in the 1990s, but has evolved to the first-line identification method in many laboratories just during the past five years. While this application of MALDI-TOF MS has proven its broad applicability, accuracy, robustness, and cost-effectiveness it is of particular interest to expand the capabilities of the mass spectrometric platform. Resistance detection is the most desirable further application of MALDI-TOF MS in microbiology, but maybe also the most challenging. Different approaches have been published regarding diverse antibiotic drugs and distinct microorganism classes. The current review shall give an overview about the developments of the recent years and their potential to get transformed in clinical useful assays in the future.
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收藏
页码：767 / 778
页数：12
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