T-Cell Abnormalities in Common Variable Immunodeficiency

被引：79

作者：

Azizi, G. ^{[1
,2
,3
]}

Rezaei, N. ^{[2
,4
,5
]}

Kiaee, F. ^{[2
,3
]}

Tavakolinia, N. ^{[2
,3
]}

Yazdani, R. ^{[6
]}

Mirshafiey, A. ^{[7
]}

Aghamohammadi, A. ^{[2
,3
]}

机构：

[1] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Dept Lab Med, Karaj, Iran

[2] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[3] USERN, Primary Immunodeficiency Dis Network PIDNet, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[5] USERN, NIIMA, Tehran, Iran

[6] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[7] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran

来源：

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY | 2016年 / 26卷 / 04期

关键词：

Common variable immunodeficiency; T cell; Helper T cells; Regulatory T cells; RECOMBINATION EXCISION CIRCLES; IN-VIVO MODULATION; B-CELL; CVID PATIENTS; CLINICAL PHENOTYPES; DIAGNOSTIC-CRITERIA; INTRAVENOUS IMMUNOGLOBULIN; PARENTAL CONSANGUINITY; IMMUNE DYSREGULATION; HELPER-CELLS;

D O I：

10.18176/jiaci.0069

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients.

引用

页码：233 / 243

页数：11

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