Conduct of Clinical Trials in Acute Heart Failure: Regional Differences in Heart Failure Clinical Trials

被引：7

作者：

Fiuzat, Mona ^{[1
]}

Califf, Robert M. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Durham, NC 27710 USA

[2] Duke Translat Med Inst, Durham, NC USA

来源：

HEART FAILURE CLINICS | 2011年 / 7卷 / 04期

关键词：

Heart failure; Regional differences; Clinical trials; BETA-BLOCKER BUCINDOLOL; QUALITY-OF-CARE; BETA(1)-ADRENERGIC RECEPTOR; MYOCARDIAL-INFARCTION; SURVIVAL TRIAL; SURVEY PROGRAM; UNITED-STATES; MERIT-HF; CIBIS-II; POLYMORPHISM;

D O I：

10.1016/j.hfc.2011.06.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical trials are often conducted globally. Differences in standard of care, patient populations including genetic and phenotypic differences, disease etiologies, rates of comorbidities, ascertainment of endpoints, and differences in concomitant therapies and medical culture may influence subsequent outcomes. There has been little consensus on how clinical trial results should be evaluated. This article reviews the differences in cardiovascular trial results by geographic region, offers potential explanations for these differences, and suggests methods for standardization of trial results.

引用

页码：539 / +

页数：7

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