Oral Premalignancy The Roles of Early Detection and Chemoprevention

被引：22

作者：

Foy, Jean-Philippe ^{[1
]}

Bertolus, Chloe ^{[1
]}

William, William N., Jr. ^{[2
]}

Saintigny, Pierre ^{[2
]}

机构：

[1] Hop La Pitie Salpetriere, Dept Maxillofacial Surg, F-75013 Paris, France

[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2013年 / 46卷 / 04期

关键词：

Head and neck cancer; Chemoprevention; Head and neck squamous cell carcinoma; Oral squamous cell carcinoma; Potentially malignant disorder; Biomarkers of risk; Loss of heterozygocity; SQUAMOUS-CELL CARCINOMA; LOW-DOSE ISOTRETINOIN; 2ND PRIMARY TUMORS; POTENTIALLY MALIGNANT DISORDERS; NECK-CANCER; LUNG-CANCER; RANDOMIZED-TRIAL; BETA-CAROTENE; FIELD CANCERIZATION; TONGUE CARCINOGENESIS;

D O I：

10.1016/j.otc.2013.04.010

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Premalignancy and chemoprevention studies in head and neck cancer typically focus on the oral cavity. Avoiding or cessation of alcohol and smoking, early detection of potentially malignant disorders or cancer, and early detection of recurrent and/or second primary tumor form the basis of prevention of oral cancer. Analysis of tissue prospectively collected in evaluation of retinoids for chemoprevention trials allowed identification of molecular biomarkers of risk to develop oral cancer, loss of heterozygosity being the most validated one. Improving risk assessment and identification of new targets for chemoprevention represent the main challenges in this field.

引用

页码：579 / +

页数：20

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