Focal Cortical Dysplasia

被引：24

作者：

Gaitanis, John N. ^{[1
]}

Donahue, John ^{[2
]}

机构：

[1] Brown Univ, Warren Alpert Sch Med, Dept Neurol & Pediat Clin, Providence, RI 02903 USA

[2] Brown Univ, Warren Alpert Sch Med, Dept Pathol & Lab Med & Neurol, Providence, RI 02903 USA

来源：

PEDIATRIC NEUROLOGY | 2013年 / 49卷 / 02期

关键词：

TUBEROUS SCLEROSIS COMPLEX; EPILEPSY SURGERY; CONSENSUS CLASSIFICATION; GENETIC CLASSIFICATION; INTRACTABLE EPILEPSY; MAMMALIAN TARGET; RAPAMYCIN; MALFORMATIONS; EXPRESSION; CORTEX;

D O I：

10.1016/j.pediatrneurol.2012.12.024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Focal cortical dysplasias are among the most common causes of intractable epilepsy in children. As the neuropathology of these conditions has been better clarified, the nomenclature has undergone numerous revisions. Their recognition has grown with the use of neuroimaging, and recent advances in imaging technology will further improve detection. Clinical, electroencephalographic, and imaging findings are often diagnostic, so it is imperative for the clinician to recognize the characteristic patterns. Treatment for developmental and behavioral disability remains largely symptomatic, and epilepsy medications are often ineffective. Epilepsy surgery, however, can be successful in selected patients. The basic science underlying the development of focal cortical dysplasias may lead to novel therapeutic approaches in the future. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：79 / 87

页数：9

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