Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing

被引:149
作者
Martin, M. A. [1 ]
Klein, T. E. [2 ]
Dong, B. J. [3 ]
Pirmohamed, M. [4 ]
Haas, D. W. [5 ,6 ,7 ]
Kroetz, D. L. [1 ]
机构
[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[3] Univ Calif San Francisco, Dept Clin Pharm, San Francisco, CA 94143 USA
[4] Univ Liverpool, Dept Pharmacol, Liverpool L69 3BX, Merseyside, England
[5] Vanderbilt Univ, Dept Med, Nashville, TN USA
[6] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA
[7] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Nashville, TN USA
基金
美国国家卫生研究院;
关键词
HUMAN-LEUKOCYTE ANTIGEN-B-ASTERISK-5701; HYPERSENSITIVITY REACTIONS; DRUG HYPERSENSITIVITY; MYOCARDIAL-INFARCTION; HLA-B-ASTERISK-5701; THERAPY; ASSOCIATION; HIV-1; MARKER; B-ASTERISK-5701;
D O I
10.1038/clpt.2011.355
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Human leukocyte antigen B (HLA-B) is responsible for presenting peptides to immune cells and plays a critical role in normal immune recognition of pathogens. A variant allele, HLA-B(star)57:01, is associated with increased risk of a hypersensitivity reaction to the anti-HIV drug abacavir. In the absence of genetic prescreening, hypersensitivity affects similar to 6% of patients and can be life-threatening with repeated dosing. We provide recommendations (updated periodically at http://www.pharmkgb.org) for the use of abacavir based on HLA-B genotype.
引用
收藏
页码:734 / 738
页数:5
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