Chitosan/Polylactic Acid/Tripolyphosphate Nanocapsules for Encapsulation of Water-Insoluble Drugs: In vitro Drug Release and Cytotoxicity

被引：83

作者：

Jin, Lian ^{[1
]}

Zeng, Xin ^{[2
]}

Liu, Ming ^{[1
]}

He, Nongyue ^{[1
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Gynecol Endocrine, State Key Lab Reprod Med, Nanjing Matern & Child Hlth Care Hosp, Nanjing 210029, Jiangsu, Peoples R China

来源：

SCIENCE OF ADVANCED MATERIALS | 2013年 / 5卷 / 12期

关键词：

Chitosan; Azithromycin; Polylactic Acid; Entrapment Efficiency; CHITOSAN NANOPARTICLES; MAGNETIC NANOPARTICLES; DELIVERY-SYSTEM; FABRICATION; MICROSPHERES; NANOFIBERS; STABILITY; GELATION; PROGRESS; CARRIER;

D O I：

10.1166/sam.2013.1747

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Much attention has been paid to chitosan-based nanoparticles for drug and gene delivery. In this study, chitosan/polylactic acid/tripolyphosphate (CS/PLA/TPP) nanoparticles were successfully prepared for encapsulation of insoluble drugs, which was confirmed by Fourier transform infrared spectroscopy (FTIR). The nanoparticles were regular, spherical and had a uniform diameter of around 300 nm. The entrapment efficiency of the obtained CS/PLA/TPP nanoparticles for azithromycin (AZI) varied with both the ratio of CS to PLA and the ratio of CS to AZI. The highest entrapment efficiency above 85% was realized, with 4:1 ratio for CS:PLA and 10:13 ratio for CS:AZI. A sustained and controlled in vitro drug release was also observed. Moreover, the CS/PLA/TPP nanoparticles showed little cytotoxicity when co-cultured with Hela and HEK293T cells. Though the CS/PLA/TPP nanoparticles are suitable for most water-insoluble drugs, the entrapment capacity for different drugs varies.

引用

页码：2053 / 2057

页数：5

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