The multiple interactions between growth factors and microenvironment in vivo

被引：4

作者：

Bo Jin'gen ^{[1
]}

Yang Jian ^{[1
]}

Zhu Dunwan ^{[1
]}

Li Junjie ^{[1
]}

Yao Kangde ^{[1
]}

机构：

[1] Tianjin Univ, Res Inst Polymer Mat, Tianjin 300072, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2006年 / 51卷 / 07期

关键词：

growth factors; extracellular matrices; signaling; microenvironment; controlled release;

D O I：

10.1007/s11434-006-0761-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell, growth factors and extracellular matrices (ECMs) coexist in a dynamic tissue environment. A knowledge of multiple interactions among them is highly important for effectively raising the biological activities of growth factors, regulating cell life cycle, designing and preparing exogenous matrices to control growth factors release in tissue or organ regeneration by engineering means. This paper addresses the characteristics and functions of growth factors, interactions between growth factors and ECMs, the manners and correlative signaling of growth factors acting on cells, and briefly summarizes the biomimetic requisites for controlled release matrices, hoping to provide a useful reference for correlative research in tissue engineering.

引用

页码：761 / 769

页数：9

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