Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

被引：263

作者：

Nakamura, Yoshiaki ^{[1
,2
]}

Taniguchi, Hiroya ^{[1
,2
]}

Ikeda, Masafumi ^{[3
]}

Bando, Hideaki ^{[4
]}

Kato, Ken ^{[5
,6
]}

Morizane, Chigusa ^{[7
]}

Esaki, Taito ^{[8
]}

Komatsu, Yoshito ^{[9
]}

Kawamoto, Yasuyuki ^{[9
]}

Takahashi, Naoki ^{[10
]}

Ueno, Makoto ^{[11
]}

Kagawa, Yoshinori ^{[12
]}

Nishina, Tomohiro ^{[13
]}

Kato, Takeshi ^{[14
]}

Yamamoto, Yoshiyuki ^{[15
]}

Furuse, Junji ^{[16
]}

Denda, Tadamichi ^{[17
]}

Kawakami, Hisato ^{[18
]}

Oki, Eiji ^{[19
]}

Nakajima, Takako ^{[20
]}

Nishida, Naohiro ^{[21
]}

Yamaguchi, Kensei ^{[22
]}

Yasui, Hisateru ^{[23
]}

Goto, Masahiro ^{[24
]}

Matsuhashi, Nobuhisa ^{[25
]}

Ohtsubo, Koushiro ^{[26
]}

Yamazaki, Kentaro ^{[27
]}

Tsuji, Akihito ^{[28
]}

Okamoto, Wataru ^{[2
,29
]}

Tsuchihara, Katsuya ^{[2
,30
]}

Yamanaka, Takeharu ^{[31
]}

Miki, Izumi ^{[2
]}

Sakamoto, Yasutoshi ^{[2
]}

Ichiki, Hiroko ^{[2
]}

Hata, Masayuki ^{[2
]}

Yamashita, Riu ^{[30
]}

Ohtsu, Atsushi ^{[1
]}

Odegaard, Justin, I ^{[32
]}

Yoshino, Takayuki ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Dept Gastroenterol & Gastrointestinal Oncol, Kashiwa, Chiba, Japan

[2] Natl Canc Ctr Hosp East, Translat Res Support Sect, Kashiwa, Chiba, Japan

[3] Natl Canc Ctr Hosp East, Dept Hepatobiliary & Pancreat Oncol, Kashiwa, Chiba, Japan

[4] Aichi Canc Ctr Hosp, Dept Clin Oncol, Nagoya, Aichi, Japan

[5] Natl Canc Ctr, Dept Gastrointestinal Oncol, Tokyo, Japan

[6] Natl Canc Ctr, Biobank Translat Res Support Sect, Tokyo, Japan

[7] Natl Canc Ctr, Dept Hepatobiliary & Pancreat Oncol, Tokyo, Japan

[8] Natl Hosp Org Kyushu Canc Ctr, Dept Gastrointestinal & Med Oncol, Fukuoka, Japan

[9] Hokkaido Univ Hosp, Dept Canc Ctr, Sapporo, Hokkaido, Japan

[10] Saitama Canc Ctr, Dept Gastroenterol, Saitama, Japan

[11] Kanagawa Canc Ctr, Dept Gastroenterol, Hepatobiliary & Pancreat Med Oncol Div, Yokohama, Kanagawa, Japan

[12] Kansai Rosai Hosp, Dept Colorectal Surg, Amagasaki, Hyogo, Japan

[13] Natl Hosp Org Shikoku Canc Ctr, Dept Gastrointestinal Med Oncol, Matsuyama, Ehime, Japan

[14] Natl Hosp Org Osaka Natl Hosp, Dept Surg, Osaka, Japan

[15] Univ Tsukuba Hosp, Dept Gastroenterol & Hepatol, Tsukuba, Ibaraki, Japan

[16] Kyorin Univ Hosp, Dept Med Oncol, Mitaka, Tokyo, Japan

[17] Chiba Canc Ctr, Div Gastroenterol, Chiba, Japan

[18] Kindai Univ Hosp, Dept Med Oncol, Osakasayama, Japan

[19] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka, Japan

[20] St Marianna Univ, Sch Med, Dept Med Oncol, Kawasaki, Kanagawa, Japan

[21] Osaka Univ, Grad Sch Med, Dept Frontier Sci Canc & Chemotherapy, Suita, Osaka, Japan

[22] Japanese Fdn Canc Res, Dept Gastroenterol Chemotherapy, Canc Inst Hosp, Tokyo, Japan

[23] Kobe City Med Ctr, Dept Med Oncol, Gen Hosp, Kobe, Hyogo, Japan

[24] Osaka Med Coll Hosp, Canc Chemotherapy Ctr, Takatsuki, Osaka, Japan

[25] Gifu Univ, Grad Sch Med, Dept Surg Oncol, Gifu, Japan

[26] Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa, Japan

[27] Shizuoka Canc Ctr, Div Gastrointestinal Oncol, Shizuoka, Japan

[28] Kagawa Univ Hosp, Dept Clin Oncol, Miki, Kagawa, Japan

[29] Hiroshima Univ Hosp, Canc Treatment Ctr, Hiroshima, Japan

[30] Natl Canc Ctr, Div Translat Informat, Exploratory Oncol Res & Clin Trial Ctr, Kashiwa, Chiba, Japan

[31] Natl Canc Ctr Hosp East, Div Biostat, Kashiwa, Chiba, Japan

[32] Guardant Hlth, Redwood City, CA USA

来源：

NATURE MEDICINE | 2020年 / 26卷 / 12期

关键词：

CELL LUNG-CANCER; CHOLANGIOCARCINOMA; MULTICENTER; VALIDATION; RESISTANCE; MUTATIONS; BIOPSIES; TRIALS;

D O I：

10.1038/s41591-020-1063-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in similar to 2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients.

引用

页码：1859 / 1864

页数：16

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