Water Dispersal and Functionalization of Hydrophobic Iron Oxide Nanoparticles with Lipid-Modified Poly(amidoamine) Dendrimers

被引：23

作者：

Boni, Adriano ^{[1
]}

Albertazzi, Lorenzo ^{[2
,3
]}

Innocenti, Claudia ^{[4
,5
]}

Gemmi, Mauro ^{[1
]}

Bifone, Angelo ^{[1
]}

机构：

[1] Ctr Nanotechnol Innovat NEST, Ist Italiano Tecnol, I-56127 Pisa, Italy

[2] Eindhoven Univ Technol, Inst Complex Mol Syst, NL-5600 MB Eindhoven, Netherlands

[3] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands

[4] Univ Florence, INSTM, I-50019 Florence, Italy

[5] Univ Florence, Dept Chem, I-50019 Florence, Italy

来源：

LANGMUIR | 2013年 / 29卷 / 35期

关键词：

MAGNETIC-RESONANCE; PHASE-TRANSFER; PAMAM DENDRIMERS; SURFACE; NANOCRYSTALS; PARTICLES; COMPLEXES; DELIVERY; SHELL;

D O I：

10.1021/la400791a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and facile method for water dispersal of hydrophobic iron oxide nanoparticles based on the amphiphilic PAMAM-C-12 dendrimer is described. Stable and highly concentrated water dispersions of multifunctional, magnetic nanoparticles were obtained with this single-step approach, and showed :interesting relaxometric properties for MRI applications. Importantly, this method does not require substitution of the native hydrophobic capping under nonmild reaction conditions, thus preserving the structural and magnetic properties of the nanoparticles, and extending the possibility of conjugation with thermally labile groups.

引用

页码：10973 / 10979

页数：7

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