Muscone suppresses myocardial ischemia damage by regulating PI3K/Akt signaling pathway

被引：11

作者：

Zhu, Li-Li ^{[1
]}

Cao, Gui-Yun ^{[2
]}

Jia, Li-Ying ^{[1
]}

Zheng, Guo ^{[1
]}

Zhang, Liang ^{[1
]}

Sheng, Ping ^{[1
]}

Meng, Zhao-Qing ^{[2
]}

He, Xin ^{[3
]}

Zhang, Chun-Feng ^{[1
]}

Wang, Chong-Zhi ^{[4
,5
]}

Yuan, Chun-Su ^{[4
,5
]}

机构：

[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing, Peoples R China

[2] Shandong Hongjitang Pharmaceut Grp Co Ltd, Inst Tradit Chinese Med, Jinan, Peoples R China

[3] Chinese Univ Hong Kong, Sch Biomed Sci, Fac Med, Hong Kong, Peoples R China

[4] Univ Chicago, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA

[5] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2022年 / 1868卷 / 12期

关键词：

Coronary heart disease; Muscone; Oxidative stress; Apoptosis; PI3K/Akt pathway; REPERFUSION INJURY; APOPTOSIS; HEART; ACTIVATION; DISEASE; PROTEIN; CELLS; RISK;

D O I：

10.1016/j.bbadis.2022.166539

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Muscone is the main active compound of Moschus. In this paper, the cardioprotective effect of Muscone on acute myocardial ischemia (AMI) rats and its potential mechanisms were investigated. AMI rat models were established to evaluate the protective effect and antioxidative function of Muscone on the hearts. Moreover, Western blot analysis was conducted to quantify the phosphorylated PI3K and AKT levels in PI3K/Akt pathway for further investigating the mechanism of Muscone. Results showed that Muscone could markedly lessen the infarct size and myocardial injury, improve cardiac function, inhibit cardiomyocyte apoptosis and down-regulate serum reactive oxygen species level as indicated by the decreased MDA, BNP and c-TnI activities and the increased SOD, GSH-px, CAT activities and the expression of Bax protein. In addition, it was revealed that Muscone notably promoted the phosphorylation of PI3K and AKT. These findings denote that Muscone exerts a protective effect in heart via inhibition of oxidative stress and apoptosis, offering new insights into the treatment of CHD and the clinical application of Muscone.

引用

页数：10

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