Radiation therapy strategies for skull-base malignancies

被引:3
作者
Palmer, J. D. [1 ,2 ]
Gamez, M. E. [1 ]
Ranta, K. [1 ]
Ruiz-Garcia, H. [3 ]
Peterson, J. L. [3 ,4 ]
Blakaj, D. M. [1 ]
Prevedello, D. [2 ,5 ]
Carrau, R. [2 ,5 ]
Mahajan, A. [6 ]
Chaichana, K. L. [4 ]
Trifiletti, D. M. [3 ,4 ]
机构
[1] Ohio State Univ, Wexner Med Ctr, Dept Radiat Oncol, James Canc Hosp, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Neurosurg, Wexner Med Ctr, James Canc Hosp, Columbus, OH 43210 USA
[3] Mayo Clin, Dept Radiat Oncol, 4500 San Pablo Rd S, Jacksonville, FL 32224 USA
[4] Mayo Clin, Dept Neurol Surg, Jacksonville, FL 32224 USA
[5] Ohio State Univ, Dept Otolaryngol Head & Neck Surg, Wexner Med Ctr, Columbus, OH 43210 USA
[6] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA
关键词
Skull base; Radiation; Intensity modulated radiation therapy; Proton therapy; Stereotactic radiosurgery; Gamma knife radiosurgery; Intensity modulated proton therapy; SINONASAL UNDIFFERENTIATED CARCINOMA; INTENSITY-MODULATED RADIOTHERAPY; CELL NEUROENDOCRINE CARCINOMA; ELECTIVE NODAL IRRADIATION; ADENOID CYSTIC CARCINOMA; NUT MIDLINE CARCINOMA; PROTON-BEAM THERAPY; LONG-TERM OUTCOMES; FRACTIONATED STEREOTACTIC RADIOTHERAPY; HEALTH-ORGANIZATION CLASSIFICATION;
D O I
10.1007/s11060-020-03569-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction The management of skull base malignancies continues to evolve with improvements in surgical technique, advances in radiation delivery and novel systemic agents. Methods In this review, we aim to discuss in detail the management of common skull base pathologies which typically require multimodality therapy, focusing on the radiotherapeutic aspects of care. Results Technological advances in the administration of radiation therapy have led to a wide variety of different treatment strategies for the treatment of skull base malignances, with outcomes summarized herein. Conclusion Radiation treatment plays a key and critical role in the management of patients with skull base tumors. Recent advancements continue to improve the risk/benefit ratio for radiotherapy in this setting.
引用
收藏
页码:445 / 462
页数:18
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