Thymic emigration: When and how T cells leave home

被引：122
作者：
Weinreich, Michael A.
Hogquist, Kristin A.
机构：
[1] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Ctr Immunol, Minneapolis, MN 55455 USA
来源：
JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 04期
关键词：
D O I：
10.4049/jimmunol.181.4.2265
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Kruppel-like transcription factor KLF2.
引用
收藏
页码：2265 / 2270
页数：6
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