Ca2+ signaling, intracellular pH and cell volume in cell proliferation

被引：100
|
作者：
Schreiber, R [1 ]
机构：
[1] Univ Regensburg, Inst Physiol, D-93053 Regensburg, Germany
来源：
JOURNAL OF MEMBRANE BIOLOGY | 2005年 / 205卷 / 03期
关键词：
cell proliferation; tumor growth; intracellular calcium; calcium signalling; calcium entry; TRP-channels; intracellular pH; pH homeostasis; sodium-proton exchanger; cell volume;
D O I：
10.1007/s00232-005-0778-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitogens control progression through the cell cycle in non-transformed cells by complex cascades of intracellular messengers, such as Ca2+ and protons, and by cell volume changes. Intracellular Ca2+ and proton concentrations are critical for linking external stimuli to proliferation, motility, apoptosis and differentiation. This review summarizes the role in cell proliferation of calcium release from intracellular stores and the Ca2+ entry through plasma membrane Ca2+ channels. In addition, the impact of intracellular pH and cell volume on cell proliferation is discussed.
引用
收藏
页码：129 / 137
页数：9
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