Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL), a novel member of the scavenger receptor family

被引：28
作者：
Nakamura, K
Funakoshi, H
Tokunaga, F
Nakamura, T
机构：
[1] Osaka Univ, Grad Sch Med, Course Adv Med, Div Mol Regenerat Med, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Sci, Dept Earth & Space Sci, Suita, Osaka 5650871, Japan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2001年 / 1522卷 / 01期
关键词：
scavenger receptor; collagen-like; C-type lectin; coiled coil; scavenger receptor with C-type lectin; J774A.1; cell;
D O I：
10.1016/S0167-4781(01)00284-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cDNA clone encoding a mouse scavenger receptor with C-type lectin (SRCL), a novel member of the scavenger receptor fan-lily, has been isolated from a mouse embryonic cDNA library. The predicted cDNA sequence contains a 2226 bp open reading frame encoding a coiled-coil, collagen-like, C-type lectin/carbohydrate recognition domain with an overall sequence identity of 92% to human SRCL. In contrast to human, mouse SRCL mRNA was expressed ubiquitously in various adult tissues including the liver and spleen, in which human SRCL mRNA was under detection limits. Mouse SRCL mRNA was expressed in the macrophage cell line J774A.1 cells at a high level and in the embryo as early as E9. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：53 / 58
页数：6
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