Pharmacokinetics of florfenicol in cerebrospinal fluid and plasma of calves

被引:56
作者
deCraene, BA
Deprez, P
DHaese, E
Nelis, HJ
VandenBossche, W
DeLeenheer, AP
机构
[1] STATE UNIV GHENT,FARMACEUT MICROBIOL LAB,B-9000 GHENT,BELGIUM
[2] STATE UNIV GHENT,KLIN INWENDIGE ZIEKTEN GROTE HUISDIEREN,B-9000 GHENT,BELGIUM
[3] STATE UNIV GHENT,LAB ONTLEDING GENEESMIDDELEN,B-9000 GHENT,BELGIUM
[4] STATE UNIV GHENT,LAB MED BIOCHEM KLIN ANAL,B-9000 GHENT,BELGIUM
关键词
D O I
10.1128/AAC.41.9.1991
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Florfenicol, a fluorinated analog of thiamphenicol, is of great value in veterinary infectious diseases that formerly responded favorably to chloramphenicol. fn view of the treatment of meningitis in calves, we studied its pharmacokinetics in the cerebrospinal fluid (CSF) and plasma of six animals. To this end, a new highperformance liquid chromatography method was developed which, unlike previous ones, uses solid-phase instead of double-phase extraction to isolate the drug, After a single intravenous dose of 20 mg/kg of body weight, a maximum concentration in CSF of 4.67 +/- 1.51 mu g/ml (n = 6) was reached, with a mean residence time of 8.7 h. The decline of florfenicol in both CSF and plasma fitted a biexponential model with elimination half-lives of 13.4 and 3.2 h, respectively. Florfenicol penetrated well into CSF, as evidenced from an availability of 46% +/- 3% relative to plasma, The levels remained above the MIC for Haemophilus somnus over a 20-h period. Our results provide evidence indicating the effectiveness of florfenicol in the treatment of bacterial meningitis of calves.
引用
收藏
页码:1991 / 1995
页数:5
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