Association of Family History With Incidence and Outcomes of Aortic Dissection

被引：41

作者：

Chen, Shao-Wei ^{[1
,2
]}

Kuo, Chang-Fu ^{[3
,4
,5
]}

Huang, Yu-Tung ^{[2
]}

Lin, Wan-Ting ^{[2
]}

Wu, Victor Chien-Chia ^{[6
]}

Chou, An-Hsun ^{[7
]}

Lin, Pyng-Jing ^{[1
]}

Chang, Shang-Hung ^{[2
,6
]}

Chu, Pao-Hsien ^{[6
]}

机构：

[1] Chang Gung Univ, Linkou Med Ctr, Chang Gung Mem Hosp, Div Thorac & Cardiovasc Surg,Dept Surg, Taoyuan, Taiwan

[2] Chang Gung Mem Hosp, Linkou Med Ctr, Ctr Big Data Analyt & Stat, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Div Rheumatol Allergy & Immunol, Taoyuan, Taiwan

[4] Chang Gung Mem Hosp, Ctr Artificial Intelligence Med, Taoyuan, Taiwan

[5] Univ Nottingham, Sch Med, Div Rheumatol Orthopaed & Dermatol, Nottingham, England

[6] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Cardiol, Taoyuan, Taiwan

[7] Chang Gung Univ, Chang Gung Mem Hosp, Linkou Med Ctr, Dept Anesthesiol, Taoyuan, Taiwan

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2020年 / 76卷 / 10期

关键词：

aortic dissection; family aggregation; family history; long-term prognosis; ANEURYSMS; RISK; MORTALITY; ATENOLOL; LOSARTAN; TRENDS;

D O I：

10.1016/j.jacc.2020.07.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Aortic dissection (AD) is a life-threatening emergency. However, the heritability and association of family history with late outcomes are unclear. OBJECTIVES The purpose of this study was to evaluate the effect of family history of AD on the incidence and prognosis of AD and estimate the heritability and environmental contribution in AD in Taiwan. METHODS Both cross-sectional and cohort studies were conducted using Taiwan National Health Insurance database. A registry parent-offspring relationship algorithm was used to reconstruct the genealogy of this population for heritability estimation. The cross-sectional study included 23,868 patients with a diagnosis of AD in 2015. The prevalence and adjusted relative risks (RRs) were evaluated, and the liability threshold model was used to examine the effects of heritability and environmental factors. Furthermore, a 1:10 propensity score-matched cohort comprising AD patients with or without a family history of AD was included to compare late outcomes in the cohort study. RESULTS A family history of AD in first-degree relatives was associated with an RR of 6.82 (95% confidence interval [CI]: 5.12 to 9.07). The heritability of AD was estimated to be 57.0% for genetic factors, and 3.1% and 40.0% for shared and nonshared environmental factors, respectively. After excluding individuals with Marfan syndrome or bicuspid aortic valve, a family history of AD was associated with an RR of 6.56 (95% CI: 4.92 to 8.77) for AD. Furthermore, patients with AD and a family history of AD had a higher risk of later aortic surgery than those with AD without a family history (subdistribution hazard ratio: 1.40; 95% CI: 1.12 to 1.76). CONCLUSIONS A family history of AD was a strong risk factor for AD. Furthermore, patients with AD with a family history of AD had a higher risk of later aortic surgery than those with no family history of AD. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：1181 / 1192

页数：12

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