Palladium-Catalyzed Direct C-H Arylation of Cyclic Enaminones with Aryl Iodides

被引：36
|
作者：
Yu, Yi-Yun
Bi, Lei
Georg, Gunda I. [1 ]
机构：
[1] Univ Minnesota, Dept Chem, Dept Med Chem, Minneapolis, MN 55414 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 12期
基金：
美国国家卫生研究院;
关键词：
PALLADIUM(II)-CATALYZED DIRECT ARYLATION; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITION; COUPLING REACTIONS; ALKALOIDS; MECHANISM; METATHESIS; COMPLEXES; HALIDES;
D O I：
10.1021/jo400830t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.
引用
收藏
页码：6163 / 6169
页数：7
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