Spark plasma sintering of biodegradable Si3N4 bioceramic with Sr, Mg and Si as sintering additives for spinal fusion

被引:31
作者
Fu, Le [1 ]
Engqvist, Hakan [1 ]
Xia, Wei [1 ]
机构
[1] Uppsala Univ, Dept Engn Sci, Appl Mat Sci, S-75121 Uppsala, Sweden
关键词
Biodegradable Si3N4 ceramic; Sintering additives; Spinal fusion; Spark plasma sintering; SILICON-NITRIDE CERAMICS; OSTEOBLAST ADHESION; MICROSTRUCTURE; RESISTANCE; BEHAVIOR;
D O I
10.1016/j.jeurceramsoc.2017.10.003
中图分类号
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Silicon nitride (Si3N4) bioceramics with standard sintering additives (Al2O3 and Y2O3) are used in spinal fusion. Alternative Si3N4 bioceramics with biologically beneficial sintering additives could lead to improved osseointegrative properties. The aim of this study is to obtain dense and strong Si3N4 bioceramics by using SrO, MgO and SiO2 as sintering additives, and evaluate the effect of these sintering additives on microstructures and properties of Si3N4 bioceramics. Raw powders with 10 wt% and 18 wt% sintering additives were sintered by spark plasma sintering. Samples sintered at 1750 degrees C, with an applied pressure of 60 MPa and a holding time of 3 min, showed the highest content of beta-Si3N4 (94.9%). The mechanical properties of the developed Si3N4 bioceramics are comparable to the mechanical properties of currently used structural Si3N4 ceramics sintered with standard sintering additives (Al2O3 and Y2O3). The highest flexural strength of the developed Si3N4 bioceramics reached 1079 MPa. Ion release results showed that Sr2+, Mg2+ and Si4+ ions kept leaching out within 10 days' immersion. The degradable Si3N4 bioceramics with adequate strength and biologically beneficial sintering additives show the promise for load bearing biomedical applications, such as spinal fusion.
引用
收藏
页码:2110 / 2119
页数:10
相关论文
共 33 条
[1]   Texture in silicon nitride seeded with silicon nitride whiskers of different sizes [J].
Bae, BC ;
Park, DS ;
Kim, YW ;
Kim, W ;
Han, BD ;
Kim, HD ;
Park, C .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2003, 86 (06) :1008-1013
[2]   Orthopedic applications of silicon nitride ceramics [J].
Bal, B. S. ;
Rahaman, M. N. .
ACTA BIOMATERIALIA, 2012, 8 (08) :2889-2898
[3]   Calcium phosphate-based resorbable ceramics:: Influence of MgO, ZnO, and SiO2 dopants [J].
Bandyopadhyay, Amit ;
Bernard, Sheldon ;
Xue, Weichang ;
Bose, Susmita .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2006, 89 (09) :2675-2688
[4]   Spark plasma sintering: A powerful tool to develop new silicon nitride-based materials [J].
Belmonte, M. ;
Gonzalez-Julian, J. ;
Miranzo, P. ;
Osendi, M. I. .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2010, 30 (14) :2937-2946
[5]   ON WHISKER TOUGHENING IN CERAMIC MATERIALS [J].
BENGISU, M ;
INAL, OT ;
TOSYALI, O .
ACTA METALLURGICA ET MATERIALIA, 1991, 39 (11) :2509-2517
[6]   Surface modulation of silicon nitride ceramics for orthopaedic applications [J].
Bock, Ryan M. ;
McEntire, Bryan J. ;
Bal, B. Sonny ;
Rahaman, Mohamed N. ;
Boffelli, Marco ;
Pezzotti, Giuseppe .
ACTA BIOMATERIALIA, 2015, 26 :318-330
[7]   A tough SIAION ceramic based on alpha-Si3N4 with a whisker-like microstructure [J].
Chen, IW ;
Rosenflanz, A .
NATURE, 1997, 389 (6652) :701-704
[8]   Highly translucent and strong ZrO2-SiO2 nanocrystalline glass ceramic prepared by sol-gel method and spark plasma sintering with fine 3D microstructure for dental restoration [J].
Fu, Le ;
Engqvist, Hakan ;
Xia, Wei .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2017, 37 (13) :4067-4081
[9]   Decreased bacteria activity on Si3N4 surfaces compared with PEEK or titanium [J].
Gorth, Deborah J. ;
Puckett, Sabrina ;
Ercan, Batur ;
Webster, Thomas J. ;
Rahaman, Mohamed ;
Bal, B. Sonny .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :4829-4840
[10]   Ordered coalescence of nanocrystallites contributing to the rapid anisotropic grain growth in silicon nitride ceramics [J].
Hu, Jianfeng ;
Shen, Zhijian .
SCRIPTA MATERIALIA, 2013, 69 (03) :270-273