Synthesis of 5′-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides

被引：4

作者：

Agrofoglio, LA ^{[1
]}

Girard, F

Fleury, F

Léonce, S

机构：

[1] Fac Sci, CNRS, ICOA, F-45067 Orleans, France

[2] Inst Rech Servier, F-92150 Suresnes, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.

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页码：599 / 600

页数：2

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