Continuous intestinal infusion of levodopa/carbidopa in advanced Parkinson's disease: efficacy, safety and patient selection

被引：0

作者：

Abbruzzese, Giovanni ^{[1
]}

Barone, Paolo ^{[2
]}

Bonuccelli, Ubaldo ^{[3
]}

Lopiano, Leonardo ^{[4
]}

Antonini, Angelo ^{[5
]}

机构：

[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16126 Genoa, Italy

[2] Univ Salerno, Campania Parkinsons & Movement Disturbances Ctr, Salerno, Italy

[3] Univ Pisa, Dept Neurosci, Neurol Unit, I-56100 Pisa, Italy

[4] Univ Turin, Dept Neurosci, I-10124 Turin, Italy

[5] IRCCS San Camillo, Dept Parkinson Dis & Movement Disorders, Venice, Italy

来源：

FUNCTIONAL NEUROLOGY | 2012年 / 27卷 / 03期

关键词：

continuous dopaminergic stimulation; deep brain stimulation; levodopa/carbidopa intestinal gel infusion; Parkinson's disease; patient selection; DEEP-BRAIN-STIMULATION; DUODENAL LEVODOPA INFUSION; MOTOR COMPLICATIONS; SUBTHALAMIC NUCLEUS; NONMOTOR SYMPTOMS; MULTICENTER; APOMORPHINE; NEUROPATHY; THERAPIES; DUODOPA;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Long-term oral therapy with levodopa is associated with the development of motor fluctuations and dyskinesia in a large percentage of patients with Parkinson's disease (PD). Motor complications are associated with a number of non-motor symptoms and have a negative impact on disability and quality of life. There are three therapeutic options available for the management of patients at this advanced stage: high frequency deep brain stimulation, continuous subcutaneous infusion of apomorphine, and continuous intestinal infusion of levodopa/carbidopa. On the basis of published data and in consideration of the risk-benefit profile of current therapeutic strategies, we here propose an algorithm to help clinicians select the most suitable treatment option for patients with advanced PD.

引用

页码：147 / 154

页数：8

共 56 条

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