Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors

被引：12

作者：

Sattigeri, Jitendra A. ^{[1
]}

Andappan, Murugaiah M. S. ^{[1
]}

Kishore, Kaushal ^{[1
]}

Thangathirupathy, Srinivasan ^{[1
]}

Sundaram, Sinduja ^{[2
]}

Singh, Shuchita ^{[2
]}

Sharma, Suchitra ^{[2
]}

Davis, Joseph A. ^{[2
]}

Chugh, Anita ^{[2
]}

Bansal, Vinay S. ^{[2
]}

机构：

[1] Ranbaxy Res Labs, Dept Med Chem, Gurgaon 122001, India

[2] Ranbaxy Res Labs, Dept Pharmacol, Gurgaon 122001, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

type; 2; diabetes; DPP-IV inhibitor; 3-azabicylo[3.1.0] hexane;

D O I：

10.1016/j.bmcl.2008.05.101

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0] hexane derivatives at P(2) region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure-activity relationship, and selectivity against related proteases are delineated. (c) 2008 Published by Elsevier Ltd.

引用

页码：4087 / 4091

页数：5

共 3 条

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