HuR, an RNA-binding protein, involved in the control of cellular differentiation

被引：0

作者：

Cherry, J ^{[1
]}

Karschner, V ^{[1
]}

Jones, H ^{[1
]}

Pekala, PH ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Biochem & Mol Biol, Greenville, NC 27858 USA

来源：

IN VIVO | 2006年 / 20卷 / 01期

关键词：

differentiation; cell cycle; RNA-binding proteins; Hu proteins; C/EBP; adipocyte; review;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HuR is an RNA-binding protein that resides predominantly in the nucleus but shuttles to the cytosol carrying mRNAs containing a uridylate-rich region in the 3'untranslated region. Data suggest that HuR is involved in the control of the differentiation process through a tightly regulated selection of mRNAs to be shuttled to the cytosol for translation. In this review, the function of HuR in the differentiation process of preadipocytes is examined in the context of specific mRNAs selected by HuR for translocation to the cytosol.

引用

页码：17 / 23

页数：7

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