Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland

被引：33
|
作者：
Di Palma, S [1 ]
Corletto, V [1 ]
Lavarino, C [1 ]
Birindelli, S [1 ]
Pilotti, S [1 ]
机构：
[1] Ist Nazl Studio & Cura Tumori, Div Pathol & Cytopathol, I-20133 Milan, Italy
来源：
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1999年 / 434卷 / 04期
关键词：
dedifferentiated acinic cell carcinoma; parotid; ploidy; proliferative activity; TP53-MSI-LOH;
D O I：
10.1007/s004280050353
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A dedifferentiated acinic cell carcinoma (AciCC) of the right parotid gland with lymph node metastases occurred in a 36-year-old woman. The tumour was associated with a bilateral well-differentiated AciCC, The two components of this tumour had different (high and low) proliferative activity measured by Mib-1 and different (aneuploid and diploid) DNA content. De spite the presence of a high-grade component, TP53 mutations, microsatellite instability (MSI) and/or loss of heterozygosity (LOH) at the p53 locus were not detected. Although the follow-up of the patient is very short, the aggressiveness of the tumour is shown by a recurrence in the right parotid within 4 months and by the rapid development of regional metastases.
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收藏
页码：361 / 365
页数：5
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