Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria

被引：73
作者：
Jamin, Augusta [1 ,2 ]
Wiebe, Matthew S. [1 ,2 ]
机构：
[1] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA
[2] Univ Nebraska, Nebraska Ctr Virol, Lincoln, NE 68583 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2015年 / 34卷
关键词：
TEMPERATURE-SENSITIVE MUTANTS; REGULATES EMERIN BINDING; CELL-CYCLE PROGRESSION; FACTOR BAF; MEMBRANE PROTEIN; LEM-DOMAIN; RETROVIRAL DNA; HOST-DEFENSE; IN-VITRO; CHROMATIN;
D O I：
10.1016/j.ceb.2015.05.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Barrier to Autointegration Factor (BAF or BANF1) is an abundant, highly conserved DNA binding protein. BAF is involved in multiple pathways including mitosis, nuclear assembly, viral infection, chromatin and gene regulation and the DNA damage response. BAF is also essential for early development in metazoans and relevant to human physiology; BANF1 mutations cause a progeroid syndrome, placing BAF within the laminopathy disease spectrum. This review summarizes previous knowledge about BAF in the context of recent discoveries about its protein partners, posttranslational regulation, dynamic subcellular localizations and roles in disease, innate immunity, transposable elements and genome integrity.
引用
收藏
页码：61 / 68
页数：8
相关论文
共 80 条
  • [11] Solution NMR structure of the barrier-to-autointegration factor-emerin complex
    Cai, Mengli
    Huang, Ying
    Suh, Jeong-Yong
    Louis, John M.
    Ghirlando, Rodolfo
    Craigie, Robert
    Clore, G. Marius
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (19) : 14525 - 14535
  • [12] Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
    Cai, ML
    Huang, Y
    Ghirlando, R
    Wilson, KL
    Craigie, R
    Clore, GM
    [J]. EMBO JOURNAL, 2001, 20 (16) : 4399 - 4407
  • [13] Capanni C, 2010, CELL CYCLE, P9
  • [14] Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution
    Capanni, Cristina
    Squarzoni, Stefano
    Cenni, Vittoria
    D'Apice, Maria Rosaria
    Gambineri, Alessandra
    Novelli, Giuseppe
    Wehnert, Manfred
    Pasquali, Renato
    Maraldi, Nadir M.
    Lattanzi, Giovanna
    [J]. CELL CYCLE, 2012, 11 (19) : 3568 - 3577
  • [15] Chalopin D, 2015, GENOME BIOL EVOL
  • [16] ISOLATION, CHARACTERIZATION, AND PHYSICAL MAPPING OF TEMPERATURE-SENSITIVE MUTANTS OF VACCINIA VIRUS
    CONDIT, RC
    MOTYCZKA, A
    SPIZZ, G
    [J]. VIROLOGY, 1983, 128 (02) : 429 - 443
  • [17] In a nutshell: Structure and assembly of the vaccinia virion
    Condit, Richard C.
    Moussatche, Nissin
    Traktman, Paula
    [J]. ADVANCES IN VIRUS RESEARCH, VOL 66, 2006, 66 : 31 - +
  • [18] Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells
    Cox, Jesse L.
    Mallanna, Sunil K.
    Ormsbee, Briana D.
    Desler, Michelle
    Wiebe, Matthew S.
    Rizzino, Angie
    [J]. JOURNAL OF CELL SCIENCE, 2011, 124 (15) : 2654 - 2665
  • [19] DNA bridging: a property shared among H-NS-like proteins
    Dame, RT
    Luijsterburg, MS
    Krin, E
    Bertin, PN
    Wagner, R
    Wuite, GJL
    [J]. JOURNAL OF BACTERIOLOGY, 2005, 187 (05) : 1845 - 1848
  • [20] Barrier-to-Autointegration Factor influences specific histone modifications
    de Oca, Rocio Montes
    Andreassen, Paul R.
    Wilson, Katherine L.
    [J]. NUCLEUS, 2011, 2 (06) : 580 - 590
12345678