Barrier to Autointegration Factor (BANF1): interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria

被引：73
作者：
Jamin, Augusta [1 ,2 ]
Wiebe, Matthew S. [1 ,2 ]
机构：
[1] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA
[2] Univ Nebraska, Nebraska Ctr Virol, Lincoln, NE 68583 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2015年 / 34卷
关键词：
TEMPERATURE-SENSITIVE MUTANTS; REGULATES EMERIN BINDING; CELL-CYCLE PROGRESSION; FACTOR BAF; MEMBRANE PROTEIN; LEM-DOMAIN; RETROVIRAL DNA; HOST-DEFENSE; IN-VITRO; CHROMATIN;
D O I：
10.1016/j.ceb.2015.05.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Barrier to Autointegration Factor (BAF or BANF1) is an abundant, highly conserved DNA binding protein. BAF is involved in multiple pathways including mitosis, nuclear assembly, viral infection, chromatin and gene regulation and the DNA damage response. BAF is also essential for early development in metazoans and relevant to human physiology; BANF1 mutations cause a progeroid syndrome, placing BAF within the laminopathy disease spectrum. This review summarizes previous knowledge about BAF in the context of recent discoveries about its protein partners, posttranslational regulation, dynamic subcellular localizations and roles in disease, innate immunity, transposable elements and genome integrity.
引用
收藏
页码：61 / 68
页数：8
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