Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels

被引：18

作者：

French, Anne T. ^{[1
,2
]}

Ogden, Rob ^{[3
]}

Eland, Cathlene ^{[4
]}

Hemani, Gibran ^{[1
]}

Pong-Wong, Ricardo ^{[1
]}

Corcoran, Brendan ^{[1
,2
]}

Summers, Kim M. ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Roslin EH25 9RG, Midlothian, Scotland

[2] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin EH25 9RG, Midlothian, Scotland

[3] Bangor Univ, Sch Biol Sci, Bangor LL57 2UW, Gwynedd, Wales

[4] Gen Probe, Livingston EH54 7EZ, W Lothian, Scotland

来源：

VETERINARY JOURNAL | 2012年 / 193卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Mitral valve disease; Cavalier King Charles Spaniel; Genome-wide association; Homozygosity mapping; DNA analysis; REGURGITATION; MUTATION; DOGS;

D O I：

10.1016/j.tvjl.2011.09.011

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The Cavalier King Charles Spaniel (CKCS) is prone to severe early onset mitral valve disease. In this study, 36 purebred CKCS dogs were evaluated for mitral valve murmur and divided into early and late onset groups. A genome-wide genetic approach was used to assess whether the condition is determined by a small number of genetic factors. There were no regions of highly discrepant homo/heterozygosity in the two groups. Similarly, there was no evidence for loci associated with mitral valve murmur in a genome-wide association study. This analysis suggests that familial occurrence of mitral valve murmur in the CKCS breed is not due to a single major gene effect, indicating that breeding strategies to eliminate the disease cannot be based on genotype information at this time. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：283 / 286

页数：4

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