Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

被引：14

作者：

Marrone, Giulia ^{[1
]}

Urciuoli, Silvia ^{[2
]}

Di Lauro, Manuela ^{[1
]}

Ruzzolini, Jessica ^{[3
]}

Ieri, Francesca ^{[2
]}

Vignolini, Pamela ^{[2
]}

Di Daniele, Francesca ^{[4
,5
]}

Guerriero, Cristina ^{[1
]}

Nediani, Chiara ^{[3
]}

Di Daniele, Nicola ^{[1
]}

Noce, Annalisa ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, UOC Internal Med Ctr Hypertens & Nephrol Unit, Dept Syst Med, I-00133 Rome, Italy

[2] Univ Florence, PHYTOLAB Pharmaceut Cosmet Food Supplement Techno, DiSIA, I-50019 Florence, Italy

[3] Univ Florence, Dept Expt & Clin Biomed Sci Mario Serio, I-50121 Florence, Italy

[4] Univ Roma Tor Vergata, Sch Appl Med, Surg Sci, I-00133 Rome, Italy

[5] Univ Roma Tor Vergata, Dept Syst Med, UOSD Dermatol, I-00133 Rome, Italy

来源：

NUTRIENTS | 2022年 / 14卷 / 20期

关键词：

cardiovascular protection; extra virgin olive oil; chronic kidney disease; inflammatory state; oxidative stress; minor phenolic compounds; atherogenic indices; carotid intima-media thickness; INTIMA-MEDIA THICKNESS; LYMPHOCYTE RATIO; RISK; INFLAMMATION; HYDROXYTYROSOL; INTERLEUKIN-6; PATHOGENESIS; DYSFUNCTION; INHIBITION; MECHANISMS;

D O I：

10.3390/nu14204265

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The high mortality related to chronic kidney disease (CKD) is not only due to the disease itself; in fact, CKD also represents an important risk factor for cardiovascular (CV) morbidity and mortality. Among the functional foods that seems to have cardioprotective action, extra virgin olive oil (EVOO) plays a pivotal health-promoting role. The aim of this study was to evaluate the possible cardioprotective effects of an EVOO containing a very high content (>900 ppm) of minor phenolic compounds (MPCs). The selected EVOO was analyzed by HPLC-DAD-MS to establish the MPC content. The Olea extract obtained from the selected EVOO was tested against the RAW 264.7 cell line in order to investigate its anti-inflammatory activity. We enrolled 40 CKD patients under conservative therapy for in vivo clinical testing. All CKD patients consumed 40 mL/day of raw EVOO for 9 weeks (T1). At baseline (T0) and at T1, we monitored the patients' blood and urinary parameters. The patients' body composition was assessed using bioelectrical impedance analysis and the carotid intima-media thickness (CIMT) using ultrasound imaging. At T1, we observed a decrease in inflammatory parameters, CIMT, and oxidative stress biomarkers. We also noticed improvements in lipid and purine metabolism, atherogenic indices, and body composition. Thus, this study highlighted the cardioprotective action of EVOO in nephropathic patients.

引用

页数：19