Symptoms and immunoglobulin development in hospital staff exposed to a SARS-CoV-2 outbreak

被引:56
作者
Brandstetter, Susanne [1 ,2 ]
Roth, Samra [1 ]
Harner, Susanne [1 ]
Buntrock-Doepke, Heike [1 ,2 ]
Toncheva, Antoaneta A. [2 ]
Borchers, Natascha [2 ]
Gruber, Rudolf [3 ]
Ambrosch, Andreas [3 ]
Kabesch, Michael [1 ,2 ]
机构
[1] Univ Regensburg, Res & Dev Campus Regensburg WECARE, Hosp St Hedwig Order St John, Regensburg, Germany
[2] Univ Regensburg, Univ Childrens Hosp Regensburg KUNO, Hosp St Hedwig Order St John, Regensburg, Germany
[3] Hosp Order St John, Inst Lab Med Microbiol & Hyg, Regensburg, Germany
关键词
antibody response; COVID-19; outbreak; pandemic; healthcare workers; immunoglobulin development; infection chain; SARS-CoV-2;
D O I
10.1111/pai.13278
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background Worldwide, the number of SARS-CoV-2 infections is increasing. Serological immunoglobulin tests may help to better understand the development of immune mechanisms against SARS-CoV-2 in COVID-19 cases and exposed but asymptomatic individuals. The aim of this study was to investigate exposure to SARS-CoV-2, symptoms, and antibody responses in a large sample of healthcare workers following a COVID-19 outbreak. Methods A COVID-19 outbreak among staff members of a major German children's and women's hospital was followed by massive RT-PCR SARS-CoV-2 tests and provided the opportunity to study symptoms, chains of infection, and SARS-CoV-2-specific antibody responses (IgG and IgA) by ELISA. Study participants were classified as COVID-19 cases, and persons with close, moderate, or no exposure to SARS-CoV-2 in the clinical setting, respectively. Results Out of 201 study participants, 31 were COVID-19 cases. While most study participants experienced many symptoms indicative for SARS-CoV-2 infection, anosmia and coughing were remarkably more frequent in COVID-19 cases. Approximately 80% of COVID-19 cases developed some specific antibody response (IgA and IgG) approximately 3 weeks after onset of symptoms. Subjects in the non-COVID-19 groups had also elevated IgG (1.8%) and IgA values (7.6%) irrespective of contact history with cases. Conclusion We found that a significant number of diseased did not develop relevant antibody responses three weeks after symptom onset. Our data also suggest that exposure to COVID-19 positive co-workers in a hospital setting is not leading to the development of measurable immune responses in a significant proportion of asymptomatic contact persons.
引用
收藏
页码:841 / 847
页数:7
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