ENHANCEMENT OF LONG-TERM DEPRESSION BY SOLUBLE AMYLOID β PROTEIN IN RAT HIPPOCAMPUS IS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR AND INVOLVES ACTIVATION OF P38MAPK, STEP AND CASPASE-3

被引：72

作者：

Chen, X. ^{[1
]}

Lin, R. ^{[1
]}

Chang, L. ^{[1
]}

Xu, S. ^{[1
]}

Wei, X. ^{[1
]}

Zhang, J. ^{[1
]}

Wang, C. ^{[1
]}

Anwyl, R. ^{[2
]}

Wang, Q. ^{[1
]}

机构：

[1] Ningbo Univ, Res Ctr Behav Sci, Sch Med, Dept Physiol, Ningbo 315211, Zhejiang, Peoples R China

[2] Univ Dublin Trinity Coll, Dept Physiol, Trinity Coll Inst Neurosci, Dublin 2, Ireland

来源：

NEUROSCIENCE | 2013年 / 253卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; amyloid beta protein; long-term depression; metabotropic glumate receptor; hippocampus; synaptic plasticity; TYROSINE PHOSPHATASE STEP; TUMOR-NECROSIS-FACTOR; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; SIGNALING PATHWAY; NMDA RECEPTORS; MOUSE MODEL; IN-VIVO; MENTAL-RETARDATION; P38; INHIBITORS;

D O I：

10.1016/j.neuroscience.2013.08.054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is reported that the amyloid-beta protein (A beta)-induced impairments in synaptic plasticity coincide with memory decline and dementia. Although A beta-induced inhibition of hippocampal long-term potentiation has been intensively investigated, the underlying mechanism of AD-enhanced long-term depression (LTD) is not clear. Here, we report that acute exposure of rat hippocampal slices to soluble A beta-enhanced LTD induced by weak low-frequency stimulation (wLFS; 1 Hz for 3 min, 180 pulses) in granule cells of the dentate gyrus. Application of LY341495 (a non-selective Group I/II metrabotropic glumate receptor (mGluR) antagonist) completely blocked A beta-enhanced LTD, whereas D-AP5 (a not selective N-methyl-D-aspartate receptor (NMDAR) antagonist) had no effect on A beta-enhanced LTD compared with controls. In addition, A beta-enhanced LTD was occluded by pre-application of 3,5-dihydroxyphenylglycine, a Group1 mGluR (mGluR1/5) agonist, suggesting A beta-enhanced LTD depends on mGluR1/5 but not NMDAR. We also report here that p38 mitogen-activated protein kinase (p38MAPK) inhibitor SB203580 and postsynaptic protein tyrosine phosphatase inhibitors phenylarsine oxide and sodium orthovanadate prevented the facilitatory effect of A beta on LTD. Application of striatal-enriched protein tyrosine phosphatase (STEP) activator MG132 facilitated induction of LTD by wLFS, but did not block following A beta-enhanced LTD induced by another wLFS. On the other hand, A beta-enhanced LTD blocked following MG132-LTD by wLFS, suggesting A beta-enhanced hippocampal LTD involves STEP activation. Application of either non-selective caspase inhibitor Z-VAD-FMK or caspase-3 selective inhibitor Z-DEVD-FMK prevented A beta-enhanced LTD. However, neither the tumor necrosis factor-alpha converting enzyme inhibitor TAPI-2 nor the mammalian target of rapamycin inhibitor rapamycin prevented the enhancement of A beta on LTD. Therefore, we conclude that soluble A beta enhances LTD in the hippocampal dentate gyrus region, and the facilitatory effect of A beta on LTD involves mGluR1/5, p38MAPK, STEP and caspase-3 activation. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：435 / 443

页数：9

共 46 条

[41] β-amyloid inhibition of long-term potentiation is mediated via tumor necrosis factor [J].

Wang, QW ;

Wu, JQ ;

Rowan, MJ ;

Anwyl, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (11) :2827-2832

[42] Block of long-term potentiation by naturally secreted and synthetic amyloid β-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 [J].

Wang, QW ;

Walsh, DM ;

Rowan, MJ ;

Selkoe, DJ ;

Anwyl, R .

JOURNAL OF NEUROSCIENCE, 2004, 24 (13) :3370-3378

[43] Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment [J].

Wong, Tak Pan ;

Howland, John G. ;

Robillard, Julie M. ;

Ge, Yuan ;

Yu, Wayne ;

Titterness, Andrea K. ;

Brebner, Karen ;

Liu, Lidong ;

Weinberg, Joanne ;

Christie, Brian R. ;

Phillips, Anthony G. ;

Wang, Yu Tian .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (27) :11471-11476

[44] Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP [J].

Xu, Jian ;

Kurup, Pradeep ;

Zhang, Yongfang ;

Goebel-Goody, Susan M. ;

Wu, Peter H. ;

Hawasli, Ammar H. ;

Baum, Matthew L. ;

Bibb, James A. ;

Lombroso, Paul J. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (29) :9330-9343

[45] The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation [J].

Zhang, Yang ;

Venkitaramani, Deepa V. ;

Gladding, Clare M. ;

Zhang, Yongfang ;

Kurup, Pradeep ;

Molnar, Elek ;

Collingridge, Graham L. ;

Lombroso, Paul J. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (42) :10561-10566

[46] Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model [J].

Zhang, Yongfang ;

Kurup, Pradeep ;

Xu, Jian ;

Carty, Nikisha ;

Fernandez, Stephanie M. ;

Nygaard, Haakon B. ;

Pittenger, Christopher ;

Greengard, Paul ;

Strittmatter, Stephen M. ;

Nairn, Angus C. ;

Lombroso, Paul J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (44) :19014-19019

← 1 2 3 4 5 →