ENHANCEMENT OF LONG-TERM DEPRESSION BY SOLUBLE AMYLOID β PROTEIN IN RAT HIPPOCAMPUS IS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR AND INVOLVES ACTIVATION OF P38MAPK, STEP AND CASPASE-3

被引：72
作者：
Chen, X. [1 ]
Lin, R. [1 ]
Chang, L. [1 ]
Xu, S. [1 ]
Wei, X. [1 ]
Zhang, J. [1 ]
Wang, C. [1 ]
Anwyl, R. [2 ]
Wang, Q. [1 ]
机构：
[1] Ningbo Univ, Res Ctr Behav Sci, Sch Med, Dept Physiol, Ningbo 315211, Zhejiang, Peoples R China
[2] Univ Dublin Trinity Coll, Dept Physiol, Trinity Coll Inst Neurosci, Dublin 2, Ireland
来源：
NEUROSCIENCE | 2013年 / 253卷
基金：
中国国家自然科学基金;
关键词：
Alzheimer's disease; amyloid beta protein; long-term depression; metabotropic glumate receptor; hippocampus; synaptic plasticity; TYROSINE PHOSPHATASE STEP; TUMOR-NECROSIS-FACTOR; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; SIGNALING PATHWAY; NMDA RECEPTORS; MOUSE MODEL; IN-VIVO; MENTAL-RETARDATION; P38; INHIBITORS;
D O I：
10.1016/j.neuroscience.2013.08.054
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is reported that the amyloid-beta protein (A beta)-induced impairments in synaptic plasticity coincide with memory decline and dementia. Although A beta-induced inhibition of hippocampal long-term potentiation has been intensively investigated, the underlying mechanism of AD-enhanced long-term depression (LTD) is not clear. Here, we report that acute exposure of rat hippocampal slices to soluble A beta-enhanced LTD induced by weak low-frequency stimulation (wLFS; 1 Hz for 3 min, 180 pulses) in granule cells of the dentate gyrus. Application of LY341495 (a non-selective Group I/II metrabotropic glumate receptor (mGluR) antagonist) completely blocked A beta-enhanced LTD, whereas D-AP5 (a not selective N-methyl-D-aspartate receptor (NMDAR) antagonist) had no effect on A beta-enhanced LTD compared with controls. In addition, A beta-enhanced LTD was occluded by pre-application of 3,5-dihydroxyphenylglycine, a Group1 mGluR (mGluR1/5) agonist, suggesting A beta-enhanced LTD depends on mGluR1/5 but not NMDAR. We also report here that p38 mitogen-activated protein kinase (p38MAPK) inhibitor SB203580 and postsynaptic protein tyrosine phosphatase inhibitors phenylarsine oxide and sodium orthovanadate prevented the facilitatory effect of A beta on LTD. Application of striatal-enriched protein tyrosine phosphatase (STEP) activator MG132 facilitated induction of LTD by wLFS, but did not block following A beta-enhanced LTD induced by another wLFS. On the other hand, A beta-enhanced LTD blocked following MG132-LTD by wLFS, suggesting A beta-enhanced hippocampal LTD involves STEP activation. Application of either non-selective caspase inhibitor Z-VAD-FMK or caspase-3 selective inhibitor Z-DEVD-FMK prevented A beta-enhanced LTD. However, neither the tumor necrosis factor-alpha converting enzyme inhibitor TAPI-2 nor the mammalian target of rapamycin inhibitor rapamycin prevented the enhancement of A beta on LTD. Therefore, we conclude that soluble A beta enhances LTD in the hippocampal dentate gyrus region, and the facilitatory effect of A beta on LTD involves mGluR1/5, p38MAPK, STEP and caspase-3 activation. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：435 / 443
页数：9
相关论文
共 46 条
[1]   Reduction of Hippocampal Apoptosis by Intracerebroventricular Administration of Extracellular Signal-Regulated Protein Kinase and/or p38 Inhibitors in Amyloid Beta Rat Model of Alzheimer's Disease: Involvement of Nuclear-Related Factor-2 and Nuclear Factor-κB [J].
Ashabi, Ghorbangol ;
Alamdary, Shabnam Zeighamy ;
Ramin, Mahmoudreza ;
Khodagholi, Fariba .
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2013, 112 (03) :145-155
[2]   ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats [J].
Ashabi, Ghorbangol ;
Ramin, Mahmoudreza ;
Azizi, Pegah ;
Taslimi, Zahra ;
Alamdary, Shabnam Zeighamy ;
Haghparast, Abbas ;
Ansari, Niloufar ;
Motamedi, Fereshteh ;
Khodagholi, Fariba .
BEHAVIOURAL BRAIN RESEARCH, 2012, 232 (01) :165-173
[3]  
Baudry M, 2012, WIRES MEMBR TRANSP S, V1, P523, DOI DOI 10.1002/WMTS.51
[4]   Tumor necrosis factor-α converting enzyme [J].
Black, RA .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (01) :1-5
[5]   Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP) [J].
Braithwaite, Steven P. ;
Adkisson, Michael ;
Leung, John ;
Nava, Adrian ;
Masterson, Brett ;
Urfer, Roman ;
Oksenberg, Donna ;
Nikolich, Karoly .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 23 (11) :2847-2856
[6]   The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex [J].
Cavalli, V ;
Vilbois, F ;
Corti, M ;
Marcote, MJ ;
Tamura, K ;
Karin, M ;
Arkinstall, S ;
Gruenberg, J .
MOLECULAR CELL, 2001, 7 (02) :421-432
[7]   Amyloid β-Protein Fragments 25-35 and 31-35 Potentiate Long-Term Depression in Hippocampal CA1 Region of Rats In Vivo [J].
Cheng, L. I. ;
Yin, Wen-Juan ;
Zhang, Jun-Fang ;
Qi, Jin-Shun .
SYNAPSE, 2009, 63 (03) :206-214
[8]   Fyn kinase induces synaptic and cognitive impairments in a Transgenic mouse model of Alzheimer's disease [J].
Chin, J ;
Palop, JJ ;
Puoliväli, J ;
Massaro, C ;
Bien-Ly, N ;
Gerstein, H ;
Scearce-Levie, K ;
Masliah, E ;
Mucke, L .
JOURNAL OF NEUROSCIENCE, 2005, 25 (42) :9694-9703
[9]   mGluR1/5-Dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE [J].
Cho, Richard W. ;
Park, Joo Min ;
Wolff, Steffen B. E. ;
Xu, Desheng ;
Hopf, Carsten ;
Kim, Jin-ah ;
Reddy, Radhika C. ;
Petralia, Ronald S. ;
Perin, Mark S. ;
Linden, David J. ;
Worley, Paul F. .
NEURON, 2008, 57 (06) :858-871
[10]   Long-term depression in the CNS [J].
Collingridge, Graham L. ;
Peineau, Stephane ;
Howland, John G. ;
Wang, Yu Tian .
NATURE REVIEWS NEUROSCIENCE, 2010, 11 (07) :459-473
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