Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

被引：77

作者：

Bernardes, Danielle ^{[1
,2
]}

Oliveira-Lima, Onesia Cristina ^{[1
]}

da Silva, Thiago Vitarelli ^{[1
]}

Fraga Faraco, Camila Cristina ^{[1
,3
]}

Leite, Hercules Ribeiro ^{[1
]}

Juliano, Maria Aparecida ^{[4
]}

dos Santos, Daniel Moreira ^{[5
]}

Bethea, John R. ^{[6
]}

Brambilla, Roberta ^{[6
]}

Orian, Jacqueline M. ^{[7
]}

Esteves Arantes, Rosa Maria ^{[3
]}

Carvalho-Tavares, Juliana ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Nucleo Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil

[2] Minist Educ Brazil, CAPES Fdn, Programa Pos Grad Ciencias Biol Fisiol Farmacol, BR-70040020 Brasilia, DF, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Patol, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil

[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Venenos & Toxinas Anim, BR-31270901 Belo Horizonte, MG, Brazil

[6] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA

[7] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 264卷 / 1-2期

关键词：

Experimental autoimmune encephalomyelitis; Exercise; BDNF; Neuroprotection; Neuroinflammation; Intravital microscopy; QUALITY-OF-LIFE; NEUROTROPHIC FACTOR; MULTIPLE-SCLEROSIS; LEUKOCYTE RECRUITMENT; SERUM-LEVELS; EXPRESSION; RECEPTOR; LESIONS; CELLS; INFLAMMATION;

D O I：

10.1016/j.jneuroim.2013.08.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：24 / 34

页数：11

共 50 条

[31] INTERLEUKIN-33 IS RELEASED IN SPINAL CORD AND SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN MICE
Chen, H.
Sun, Y.
Lai, L.
Wu, H.
Xiao, Y.
Ming, B.
Gao, M.
Zou, H.
Xiong, P.
Xu, Y.
Tan, Z.
Gong, F.
Zheng, F.
NEUROSCIENCE, 2015, 308 : 157 - 168
[32] Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis
Dasgupta, Anushka
Zheng, Jianzheng
Perrone-Bizzozero, Nora I.
Bizzozero, Oscar A.
ASN NEURO, 2013, 5 (02): : 99 - U114
[33] Proteome analysis of spinal cord during the clinical course of monophasic experimental autoimmune encephalomyelitis
Farias, Alessandro S.
Martins-de-Souza, Daniel
Guimaraes, Leandro
Pradella, Fernando
Moraes, Adriel S.
Facchini, Gustavo
Novello, Jose Camillo
Santos, Leonilda M. B.
PROTEOMICS, 2012, 12 (17) : 2656 - 2662
[34] 2-BFI attenuates experimental autoimmune encephalomyelitis-induced spinal cord injury with enhanced B-CK, CaATPase, but reduced calpain activity
Wang, Pei
Wang, Zhao-Wei
Lin, Fu-Hong
Han, Zhao
Hou, Sheng-Tao
Zheng, Rong-Yuan
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 406 (01) : 152 - 157
[35] Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis
Rossi, Barbara
Dusi, Silvia
Angelini, Gabriele
Bani, Alessandro
Lopez, Nicola
Della Bianca, Vittorina
Pietronigro, Enrica Caterina
Zenaro, Elena
Zocco, Carlotta
Constantin, Gabriela
FRONTIERS IN IMMUNOLOGY, 2023, 14
[36] Immunohistochemical Study of Netrin-1 in the Spinal Cord with Rat Experimental Autoimmune Encephalomyelitis
Moon, Changjong
Ahn, Meejung
Jeong, Chanwoo
Kim, Heechul
Shin, Taekyun
IMMUNOLOGICAL INVESTIGATIONS, 2011, 40 (02) : 160 - 171
[37] Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis
Brouwer, N
Zuurman, MW
Wei, T
Ransohoff, RM
Boddeke, HWGM
Biber, K
GLIA, 2004, 46 (01) : 84 - 94
[38] The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis
Kamizato, Kenyu
Sato, Sho
Shil, Subrata Kumar
Umaru, Banlanjo A.
Kagawa, Yoshiteru
Yamamoto, Yui
Ogata, Masaki
Yasumoto, Yuki
Okuyama, Yuko
Ishii, Naoto
Owada, Yuji
Miyazaki, Hirofumi
NEUROSCIENCE, 2019, 409 : 120 - 129
[39] Upregulation of C-X-C motif chemokine 12 in the spinal cord alleviated the symptoms of experimental autoimmune encephalomyelitis in Lewis rats
Lin, Dahe
Liu, Hongjuan
Song, Honglu
Chen, Biyue
Fu, Junxia
Sun, Mingming
Zhou, Huanfen
Bai, Wenhao
Wei, Shihui
Li, Hongen
FRONTIERS IN NEUROSCIENCE, 2023, 17
[40] Cornuside ameliorated experimental autoimmune encephalomyelitis by limiting the recruitment of CD4+ T lymphocytes in the spinal cord
Zhang, Rongbo
Zhang, Shuijing
Xu, Bin
Wu, You
Liang, Shunli
Hou, Bonan
Wang, Mimi
Liu, Jin
Yuan, Qiang
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 58

← 1 2 3 4 5 →