Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

被引：77

作者：

Bernardes, Danielle ^{[1
,2
]}

Oliveira-Lima, Onesia Cristina ^{[1
]}

da Silva, Thiago Vitarelli ^{[1
]}

Fraga Faraco, Camila Cristina ^{[1
,3
]}

Leite, Hercules Ribeiro ^{[1
]}

Juliano, Maria Aparecida ^{[4
]}

dos Santos, Daniel Moreira ^{[5
]}

Bethea, John R. ^{[6
]}

Brambilla, Roberta ^{[6
]}

Orian, Jacqueline M. ^{[7
]}

Esteves Arantes, Rosa Maria ^{[3
]}

Carvalho-Tavares, Juliana ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Nucleo Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil

[2] Minist Educ Brazil, CAPES Fdn, Programa Pos Grad Ciencias Biol Fisiol Farmacol, BR-70040020 Brasilia, DF, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Patol, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil

[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Venenos & Toxinas Anim, BR-31270901 Belo Horizonte, MG, Brazil

[6] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA

[7] La Trobe Univ, Dept Biochem, Bundoora, Vic 3086, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 264卷 / 1-2期

关键词：

Experimental autoimmune encephalomyelitis; Exercise; BDNF; Neuroprotection; Neuroinflammation; Intravital microscopy; QUALITY-OF-LIFE; NEUROTROPHIC FACTOR; MULTIPLE-SCLEROSIS; LEUKOCYTE RECRUITMENT; SERUM-LEVELS; EXPRESSION; RECEPTOR; LESIONS; CELLS; INFLAMMATION;

D O I：

10.1016/j.jneuroim.2013.08.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：24 / 34

页数：11

共 54 条

[1] The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice [J].