Clinicopathological characteristics of follicular lymphoma with peripheral blood involvement

被引:11
|
作者
Maeshima, Akiko Miyagi [1 ]
Taniguchi, Hirokazu [1 ]
Tanioka, Kensaku [1 ]
Kitahara, Hideaki [2 ]
Miyamoto, Ken-Ichi [2 ]
Fukuhara, Suguru [2 ]
Munakata, Wataru [2 ]
Suzuki, Tatsuya [2 ]
Maruyama, Dai [2 ]
Kobayashi, Yukio [2 ]
Tobinai, Kensei [2 ]
Kushima, Ryoji [1 ]
机构
[1] Natl Canc Ctr, Dept Pathol & Clin Lab, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Dept Hematol, Tokyo 1040045, Japan
关键词
Follicular lymphoma; peripheral blood; leukemic phase; CD10; rituximab; NON-HODGKINS-LYMPHOMA; LEUKEMIC PHASE; FREQUENCY; BIOPSY; ZONE;
D O I
10.3109/10428194.2014.963578
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This study aimed to indicate patient outcomes and pathological characteristics of follicular lymphoma (FL) with peripheral blood (PB) involvement. Of 533 patients with FL, 56 (11%) had PB involvement. Of the patients treated with rituximab, 39 patients with PB involvement had significantly shorter progression-free survival than 107 patients with stage IV disease without PB involvement (p = 0.021), but the overall survival was not different (p = 0.804). The histopathology of the primary sites was usually nodal (95%) low-grade (86%) FL with IGH/BCL2 fusion (75%). Flow cytometric and immunohistochemical analyses revealed that the incidence of CD10 positivity was lower in the bone marrow (55% and 58%) and PB (41% and notavailable) than in the primary site (86% and 93%) (p = 0.004 and p = 0.0001, respectively). Therefore, even if small lymphoma cells in the bone marrow and PB are negative for CD10, FL cannot be ruled out.
引用
收藏
页码:2000 / 2004
页数:5
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