Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis

被引：15

作者：

Duan, Xiaobo ^{[1
,2
]}

Chen, Xiaolei ^{[3
]}

Gupta, Megha ^{[4
]}

Seriwatanachai, Dutmanee ^{[5
]}

Xue, Hanxiao ^{[1
,2
]}

Xiong, Qiuchan ^{[1
,2
]}

Xu, Tong ^{[1
,2
]}

Li, Dan ^{[1
,2
]}

Mo, Anchun ^{[6
]}

Tang, Xi ^{[3
]}

Zhou, Xuedong ^{[1
,2
]}

Li, Yuqing ^{[1
,2
]}

Yuan, Quan ^{[1
,2
,4
]}

机构：

[1] Sichuan Univ, State Key Lab Oral Dis, West China Hosp Stomatol, 14,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, West China Hosp Stomatol, 14,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Nephrol, Chengdu, Peoples R China

[4] Jazan Univ, Dept Prevent Dent Sci, Div Pedodont, Coll Dent, Al Showajra Acad Campus, Jazan, Saudi Arabia

[5] Mahidol Univ, Dept Oral Biol, Fac Dent, Bangkok, Thailand

[6] Sichuan Univ, West China Hosp Stomatol, Dept Oral Implantol, Chengdu, Peoples R China

来源：

BMC NEPHROLOGY | 2020年 / 21卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Saliva; Oral microbiome; Hemodialysis; Periodontal disease; CHRONIC KIDNEY-DISEASE; NON-SUBMERGED IMPLANTS; STAGE RENAL-DISEASE; MARGINAL BONE LOSS; ORAL-HEALTH; PERIODONTAL-DISEASE; MORTALITY; DIAGNOSIS; CANCER; RISK;

D O I：

10.1186/s12882-020-02009-y

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundChronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investigate the periodontal status of HD patients and its relationship with salivary microbiome.MethodsOne hundred eight HD patients and one hundred healthy control individuals were recruited. They were subjected to periodontal examination followed by saliva samples collection for 16S rRNA gene sequencing.ResultsThe HD patients were with worse periodontal health status, and exhibited higher salivary microbial diversity and lower richness. The periodontal pathogens were significantly enriched in the HD patients. The inferred functional analyze showed microbes enriched in the HD patients were mainly related to metabolism. Despite the periodontal status and overall structure of the microbiome were not significantly altered as the HD duration prolonged, the abundance of Lachnospiraceae [G-2] sp. |HMT_096| is positively correlated with the duration of HD and the community periodontal index (CPI). Five OTUs (operational taxonomic units) belonging to the phyla Firmicutes were enriched as the duration prolonged, and four OTUs originated from the phyla Proteobacteria were negatively related with the CPI index. ESRD patients undergoing HD exhibited microbiota structural, compositional and functional differences compared with the healthy controls. And the species changed as the duration of hemodialysis prolonged.ConclusionsEnd stage renal disease changes salivary microbiome and is a risk factor for oral dysbiosis.

引用

页数：11

共 55 条

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