Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones

被引：24
作者：
Brisse, S
Fluit, AC
Wagner, U
Heisig, P
Milatovic, D
Verhoef, J
Scheuring, S
Köhrer, K
Schmitz, FJ
机构：
[1] Univ Utrecht, Eijkman Winkler Inst, NL-3585 CX Utrecht, Netherlands
[2] Univ Hosp Dusseldorf, Inst Med Microbiol & virol, D-40225 Dusseldorf, Germany
[3] Univ Bonn, Inst Pharmaceut Microbiol, D-5300 Bonn, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期
关键词：
D O I：
10.1128/AAC.43.10.2513
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.
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页码：2513 / 2516
页数：4
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