IL-10 control of dendritic cells in the skin

被引：13

作者：

Clausen, Bjorn E. ^{[1
,2
]}

Girard-Madoux, Mathilde J. H. ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, D-55122 Mainz, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

conditional gene targeting; contact hypersensitivity; dendritic cells; immune regulation; interleukin-10; IL-10 receptor signaling; Langerhans cells; skin; CONTACT HYPERSENSITIVITY; LANGERHANS CELLS; INTERLEUKIN-10; RESPONSES; INFLAMMATION;

D O I：

10.4161/onci.23186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Dendritic cell (DC)-specific IL-10 receptor knockout mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key role of DCs in the maintenance of local immune homeostasis, beyond their classical function as regulators of T-cell priming in lymph nodes.

引用

页数：3

共 50 条

[41] IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation
Dolch, Anja
Kunz, Stefanie
Dorn, Britta
Alessandrini, Francesca
Mueller, Werner
Jack, Robert S.
Martin, Stefan F.
Roers, Axel
Jakob, Thilo
EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 (02) : 302 - 312
[42] IL-10 Modulates Placental Responses to TLR Ligands
Bayraktar, Mehmet
Peltier, Morgan
Vetrano, Anna
Arita, Yuko
Gurzenda, Ellen
Joseph, Ansamma
Kazzaz, Jeffrey
Sharma, Surendra
Hanna, Nazeeh
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2009, 62 (06) : 390 - 399
[43] Involvement of IL-10 gene polymorphism (rs1800896) and IL-10 level in the development of periimplantitis
Taha, Ghada I.
MINERVA DENTAL AND ORAL SCIENCE, 2024, 73 (05) : 264 - 271
[44] IL-10 promoter hypomethylation is associated with increased IL-10 expression and poor survival in hepatocellular carcinoma
Zhang, Xianjing
Lu, Mingzhu
Xu, Yun
He, Guangzhao
Liu, Qian
Zhu, Jing
Zhang, Changsong
Zhang, Xiaoli
TRANSLATIONAL CANCER RESEARCH, 2019, 8 (04) : 1466 - 1475
[45] Etv5 Regulates IL-10 Production in Th Cells
Koh, Byunghee
Hufford, Matthew M.
Sun, Xin
Kaplan, Mark H.
JOURNAL OF IMMUNOLOGY, 2017, 198 (05) : 2165 - 2171
[46] NOD Dendritic Cells Stimulated with Lactobacilli Preferentially Produce IL-10 versus IL-12 and Decrease Diabetes Incidence
Manirarora, Jean N.
Parnell, Sarah A.
Hu, Yoon-Hyeon
Kosiewicz, Michele M.
Alard, Pascale
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,
[47] Immunosuppression induced by immature dendritic cells is mediated by TGF-β/IL-10 double-positive CD4+ regulatory T cells
Cools, N.
Van Tendeloo, V. F. I.
Smits, E. L. J. M.
Lenjou, M.
Nijs, G.
Van Bockstaele, D. R.
Berneman, Z. N.
Ponsaerts, P.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2008, 12 (02) : 690 - 700
[48] Enhanced IL-10 production by CD4+ T cells primed in IL-15Rα-deficient mice
Chow, Kai-Ping N.
Lee, Jan-Mou
Qiu, Jian-Tai
Liao, Shuen-Kuei
Lin, Shih-Chieh
Hsu, Shuo-Lun
Wu, Ning-Ning
Lin, Yen-Fu
Wu, Tzong-Shoon
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (11) : 3146 - 3156
[49] Dendritic cells activate autologous T cells and induce IL-4 and IL-10 production in myasthenia gravis
Adikari, SB
Lefvert, AK
Pirskanen, R
Press, R
Link, H
Huang, YM
JOURNAL OF NEUROIMMUNOLOGY, 2004, 156 (1-2) : 163 - 170
[50] CpG-ODN Signaling via Dendritic Cells-Expressing MyD88, but Not IL-10, Inhibits Allergic Sensitization
Alberca, Ricardo Wesley
Gomes, Eliane
Russo, Momtchilo
VACCINES, 2021, 9 (07)

← 1 2 3 4 5 →