IL-10 control of dendritic cells in the skin

被引：13

作者：

Clausen, Bjorn E. ^{[1
,2
]}

Girard-Madoux, Mathilde J. H. ^{[1
]}

机构：

[1] Univ Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, D-55122 Mainz, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期

关键词：

conditional gene targeting; contact hypersensitivity; dendritic cells; immune regulation; interleukin-10; IL-10 receptor signaling; Langerhans cells; skin; CONTACT HYPERSENSITIVITY; LANGERHANS CELLS; INTERLEUKIN-10; RESPONSES; INFLAMMATION;

D O I：

10.4161/onci.23186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Dendritic cell (DC)-specific IL-10 receptor knockout mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key role of DCs in the maintenance of local immune homeostasis, beyond their classical function as regulators of T-cell priming in lymph nodes.

引用

页数：3

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