Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

被引：32

作者：

Bernat, Zofia ^{[1
]}

Szymanowska, Anna ^{[2
]}

Kciuk, Mateusz ^{[3
,4
]}

Kotwica-Mojzych, Katarzyna ^{[5
]}

Mojzych, Mariusz ^{[1
]}

机构：

[1] Siedlce Univ Nat Sci & Humanities, Dept Chem, 3 Maja 54, PL-08110 Siedlce, Poland

[2] Med Univ Bialystok, Dept Biotechnol, Kilinskiego 1, PL-15222 Bialystok, Poland

[3] Univ Lodz, Dept Mol Biotechnol & Genet, Lab Cytogenet, Banacha 12-16, PL-90237 Lodz, Poland

[4] Univ Lodz, Doctoral Sch Exact & Nat Sci, Banacha St 12-16, PL-90237 Lodz, Poland

[5] Med Univ Lublin, Coll Med, Dept Histol Embryol & Cytophysiol, Radziwillowska 11, PL-20080 Lublin, Poland

来源：

MOLECULES | 2020年 / 25卷 / 17期

关键词：

pyrazolo[4; 3-e][1; 2; 4]triazines; anticancer activity; sulfonamides; 1; 4-triazine; fused tetrazole derivatives; fluviols; CARBONIC-ANHYDRASE INHIBITORS; ORGANIC-SYNTHESIS; PROTEIN; 1,2,4-TRIAZINES; FAMILY; PHENYLHYDRAZONES; SULFONAMIDES; NOSTOCINE; TARGETS; CLONING;

D O I：

10.3390/molecules25173948

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

引用

页数：20

共 51 条

[31] Carbonic anhydrase inhibitors and the management of cancer [J].

Pastorekova, Silvia ;

Kopacek, Juraj ;

Pastorek, Jaromir .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (09) :865-878

[32] STI-571: an anticancer protein-tyrosine kinase inhibitor [J].

Roskoski, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (04) :709-717

[33]

Roskoski R., 2007, XPHARM COMPREHENSIVE

[34] The ErbB/HER family of protein-tyrosine kinases and cancer [J].

Roskoski, Robert, Jr. .

PHARMACOLOGICAL RESEARCH, 2014, 79 :34-74

[35] A concise route to a key intermediate in the total synthesis of sempervirine [J].

Rykowski, A ;

Lipinska, T .

SYNTHETIC COMMUNICATIONS, 1996, 26 (23) :4409-4414

[36] A new synthesis of pyrazolo[4,3-e][1,2,4]triazines via acid promoted ring closure of the phenylhydrazones of 5-acyl-1,2,4-triazines [J].

Rykowski, A ;

Mojzych, M ;

Karczmarzyk, Z .

HETEROCYCLES, 2000, 53 (10) :2175-+

[37] REACTIONS OF ORGANIC-ANIONS .126. REACTION OF 1,2,4-TRIAZINES WITH NITRONATE ANIONS, DIRECT NUCLEOPHILIC ACYLATION OF 1,2,4-TRIAZINES [J].

RYKOWSKI, A ;

MAKOSZA, M .

TETRAHEDRON LETTERS, 1984, 25 (42) :4795-4796

[38] Anticancer and antiviral sulfonamides [J].

Scozzafava, A ;

Owa, T ;

Mastrolorenzo, A ;

Supuran, CT .

CURRENT MEDICINAL CHEMISTRY, 2003, 10 (11) :925-953

[39] Carbonic anhydrase inhibitors and activators and their use in therapy [J].

Scozzafava, Andrea ;

Mastrolorenzo, Antonio ;

Supuran, Claudiu T. .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (12) :1627-1664

[40]

Shah SSA, 2013, MINI-REV MED CHEM, V13, P70

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