Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

被引：27

作者：

Bernat, Zofia ^{[1
]}

Szymanowska, Anna ^{[2
]}

Kciuk, Mateusz ^{[3
,4
]}

Kotwica-Mojzych, Katarzyna ^{[5
]}

Mojzych, Mariusz ^{[1
]}

机构：

[1] Siedlce Univ Nat Sci & Humanities, Dept Chem, 3 Maja 54, PL-08110 Siedlce, Poland

[2] Med Univ Bialystok, Dept Biotechnol, Kilinskiego 1, PL-15222 Bialystok, Poland

[3] Univ Lodz, Dept Mol Biotechnol & Genet, Lab Cytogenet, Banacha 12-16, PL-90237 Lodz, Poland

[4] Univ Lodz, Doctoral Sch Exact & Nat Sci, Banacha St 12-16, PL-90237 Lodz, Poland

[5] Med Univ Lublin, Coll Med, Dept Histol Embryol & Cytophysiol, Radziwillowska 11, PL-20080 Lublin, Poland

来源：

MOLECULES | 2020年 / 25卷 / 17期

关键词：

pyrazolo[4; 3-e][1; 2; 4]triazines; anticancer activity; sulfonamides; 1; 4-triazine; fused tetrazole derivatives; fluviols; CARBONIC-ANHYDRASE INHIBITORS; ORGANIC-SYNTHESIS; PROTEIN; 1,2,4-TRIAZINES; FAMILY; PHENYLHYDRAZONES; SULFONAMIDES; NOSTOCINE; TARGETS; CLONING;

D O I：

10.3390/molecules25173948

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.

引用

页数：20

共 51 条

[1] Synthesis of 5-substituted 1,3-dimethylpyrazolo[4,3-e][1,2,4]triazines
Abu Safieh, Kayed A.
Abu Mahthieh, Ahmad M.
El-Abadelah, Mustafa M.
Ayoub, Mikdad T.
Voelter, Wolfgang
[J]. MONATSHEFTE FUR CHEMIE, 2007, 138 (02): : 157 - 160
[2] BADR MZA, 1982, INDIAN J CHEM B, V21, P115
[3] Imidazo[1,2-b]pyridazines:: a potent and selective class of cyclin-dependent kinase inhibitors
Byth, KF
Cooper, N
Culshaw, JD
Heaton, DW
Oakes, SE
Minshull, CA
Norman, RA
Pauptit, RA
Tucker, JA
Breed, J
Pannifer, A
Rowsell, S
Stanway, JJ
Valentine, AL
Thomas, AP
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (09) : 2249 - 2252
[4] Multinuclear magnetic resonance study of the structure and tautomerism of azide and iminophosphorane derivatives of chloropyridazines
Cmoch, P
[J]. MAGNETIC RESONANCE IN CHEMISTRY, 2002, 40 (08) : 507 - 516
[5] Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia
Cowan-Jacob, Sandra W.
Fendrich, Gabriele
Floersheimer, Andreas
Furet, Pascal
Liebetanz, Janis
Rummel, Gabriele
Rheinberger, Paul
Centeleghe, Mario
Fabbro, Doriano
Manley, Paul W.
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2007, 63 : 80 - 93
[6] Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines
Gucky, Tomas
Frysova, Iveta
Slouka, Jan
Hajduch, Marian
Dzubak, Petr
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) : 891 - 900
[7] Hirata K, 1996, HETEROCYCLES, V43, P1513
[8] Synthesis and structure of a novel mesomeric betaine 6,7-dimethyl-2H-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine
Karczmarzyk, Zbigniew
Mojzych, Mariusz
Rykowski, Andrzej
[J]. JOURNAL OF MOLECULAR STRUCTURE, 2007, 829 (1-3) : 22 - 28
[9] Synthesis of the pyrazolo[4,3-e][1,2,4]triazine family of natural products:: Nostocine A, fluviol A, and pseudoiodinine
Kelly, TR
Elliott, EL
Lebedev, R
Pagalday, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (17) : 5646 - 5647
[10] Kleemann A., 1999, PHARM SUBSTANCES SYN

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