Medication adherence in a comparative effectiveness trial for bipolar disorder

被引：25

作者：

Sylvia, L. G. ^{[1
]}

Reilly-Harrington, N. A. ^{[1
]}

Leon, A. C. ^{[2
]}

Kansky, C. I. ^{[1
]}

Calabrese, J. R. ^{[3
]}

Bowden, C. L. ^{[4
]}

Ketter, T. A. ^{[5
]}

Friedman, E. S. ^{[6
]}

Iosifescu, D. V. ^{[7
]}

Thase, M. E. ^{[8
]}

Ostacher, M. J. ^{[5
]}

Keyes, M. ^{[9
]}

Rabideau, D. ^{[10
]}

Nierenberg, A. A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Boston, MA USA

[2] Weill Cornell Med Coll, New York, NY USA

[3] Case Western Reserve Univ, Cleveland, OH 44106 USA

[4] Univ Texas Hlth Sci, San Antonio, TX USA

[5] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[6] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[7] Mt Sinai Sch Med, New York, NY USA

[8] Univ Penn, Philadelphia, PA 19104 USA

[9] Harvard Clin Res Inst, Boston, MA USA

[10] Massachusetts Gen Hosp, Ctr Biostat, Boston, MA 02114 USA

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2014年 / 129卷 / 05期

关键词：

bipolar disorder; compliance; psychopharmacology; NEUROPSYCHIATRIC INTERVIEW MINI; MODERATE-DOSE-USE; TREATMENT NONADHERENCE; LITHIUM-TREATMENT; MAINTENANCE; PREDICTORS; SCALE; DISCONTINUATION; INDIVIDUALS; VALIDITY;

D O I：

10.1111/acps.12202

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective Psychopharmacology remains the foundation of treatment for bipolar disorder, but medication adherence in this population is low (range 20-64%). We examined medication adherence in a multisite, comparative effectiveness study of lithium. Method The Lithium Moderate Dose Use Study (LiTMUS) was a 6-month, six-site, randomized effectiveness trial of adjunctive moderate dose lithium therapy compared with optimized treatment in adult out-patients with bipolar I or II disorder (N=283). Medication adherence was measured at each study visit with the Tablet Routine Questionnaire. Results We found that 4.50% of participants reported missing at least 30% of their medications in the past week at baseline and non-adherence remained low throughout the trial (<7%). Poor medication adherence was associated with more manic symptoms and side-effects as well as lower lithium serum levels at mid- and post-treatment, but not with poor quality of life, overall severity of illness, or depressive symptoms. Conclusion Participants in LiTMUS were highly adherent with taking their medications. The lack of association with possible predictors of adherence, such as depression and quality of life, could be explained by the limited variance or other factors as well as by not using an objective measure of adherence.

引用

页码：359 / 365

页数：7

共 36 条

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