High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) Against TNF-α and IL-6 levels In Rats

The aim of this study was to investigate the effect of exercise with High Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) on inflammatory profile of proinflammatory cytokines TNF-alpha and IL-6 on the subject of obesity.This research is used 39 wistar rats of male-sex obesity. Intervention training is given for 6 weeks with frequency 4 times per week, HIIT intensity (90-100% of base line capability), MIT (60-80% of base line capability) TNF-alpha and IL-6 levels are obtained from blood testing with using ELISA test. Data analysis using Anova test.The results of this study showed that there were differences in levels of TNF-alpha HIIT with control (P = 0.003), MIT with control (P = 0.001) and no difference between HIIT group and MIT (P = 0.945). There was a difference of IL-6 levels between HIIT and control (P = 0.000), HIIT with MIT (P = 0.002), no difference in MIT group with control (P = 0.747). Exercise with the method of HIIT and MIT for 6 weeks with a frequency of 4 times per week can not create levels of TNF-alpha on the subject of obesity are lower as compared with sedentary groups, even the levels of TNF-alpha group of HIIT and MIT were significantly higher compared with the sedentary group. As for the levels of IL-6, HIIT is more effective in influencing the low IL-6 compared to MIT.