Is the neutrophil-to-lymphocyte ratio a useful prognostic indicator in melanoma patients?

被引：35

作者：

Cohen, Joshua T. ^{[1
]}

Miner, Thomas J. ^{[1
]}

Vezeridis, Michael P. ^{[1
]}

机构：

[1] Brown Univ, Rhode Isl Hosp, Dept Surg, Warren Alpert Med Sch, Providence, RI 02903 USA

来源：

MELANOMA MANAGEMENT | 2020年 / 7卷 / 03期

关键词：

immunotherapy; melanoma; neutrophil-to-lymphocyte ratio; prognosis; INDUCED IMMUNOSUPPRESSION; CANCER-IMMUNOTHERAPY; SUPPRESSOR-CELLS; UP-REGULATION; SURVIVAL; IPILIMUMAB; COMBINATION; MULTICENTER; PREDICTOR; MECHANISM;

D O I：

10.2217/mmt-2020-0006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The neutrophil-to-lymphocyte ratio (NLR) is gaining traction as a biomarker with utility in a variety of malignancies including melanoma. Intact lymphocyte function is necessary for tumor surveillance and destruction, and neutrophils play a role in suppressing lymphocyte proliferation and in the induction of lymphocyte apoptosis. Early research in melanoma indicates that in high-risk localized melanoma, a high NLR is correlated with worse overall and disease-free survival. Similarly, in metastatic melanoma treated with both metastasectomy and immunotherapies, an elevated NLR is predictive of shortened overall survival and progression-free survival. Future studies incorporating NLR into more traditional melanoma prognostic markers while employing more granular outcomes, are needed to realize the full potential of NLR.

引用

页数：9

共 71 条

[21] Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab [J].

Ferrucci, P. F. ;

Ascierto, P. A. ;

Pigozzo, J. ;

Del Vecchio, M. ;

Maio, M. ;

Cappellini, G. C. Antonini ;

Guidoboni, M. ;

Queirolo, P. ;

Savoia, P. ;

Mandala, M. ;

Simeone, E. ;

Valpione, S. ;

Altomonte, M. ;

Spagnolo, F. ;

Cocorocchio, E. ;

Gandini, S. ;

Giannarelli, D. ;

Martinoli, C. .

ANNALS OF ONCOLOGY, 2016, 27 (04) :732-738

[22] A high neutrophil to lymphocyte ratio prior to BRAF inhibitor treatment is a predictor of poor progression-free survival in patients with metastatic melanoma [J].

Finon, Antoine ;

Zaragoza, Julia ;

Maillard, Herve ;

Beneton, Nathalie ;

Bens, Guido ;

Samimi, Mahtab ;

Caille, Agnes ;

Machet, Laurent .

EUROPEAN JOURNAL OF DERMATOLOGY, 2018, 28 (01) :38-43

[23] Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].

Fridlender, Zvi G. ;

Sun, Jing ;

Kim, Samuel ;

Kapoor, Veena ;

Cheng, Guanjun ;

Ling, Leona ;

Worthen, G. Scott ;

Albelda, Steven M. .

CANCER CELL, 2009, 16 (03) :183-194

[24] Baseline neutrophil to lymphocyte ratio combined with serum lactate dehydrogenase level associated with outcome of nivolumab immunotherapy in a Japanese advanced melanoma population [J].

Fujisawa, Y. ;

Yoshino, K. ;

Otsuka, A. ;

Funakoshi, T. ;

Fujimura, T. ;

Yamamoto, Y. ;

Hata, H. ;

Tanaka, R. ;

Yamaguchi, K. ;

Nonomura, Y. ;

Hirai, I. ;

Furudate, S. ;

Okuhira, H. ;

Imafuku, K. ;

Aoki, M. ;

Matsushita, S. .

BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (01) :213-215

[25] Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual [J].

Gershenwald, Jeffrey E. ;

Scolyer, Richard A. ;

Hess, Kenneth R. ;

Sondak, Vernon K. ;

Long, Georgina V. ;

Ross, Merrick I. ;

Lazar, Alexander J. ;

Faries, Mark B. ;

Kirkwood, John M. ;

McArthur, Grant A. ;

Haydu, Lauren E. ;

Eggermont, Alexander M. M. ;

Flaherty, Keith T. ;

Balch, Charles M. ;

Thompson, John F. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (06) :472-492

[26] Roles of the immune system in cancer: from tumor initiation to metastatic progression [J].

Gonzalez, Hugo ;

Hagerling, Catharina ;

Werb, Zena .

GENES & DEVELOPMENT, 2018, 32 (19-20) :1267-1284

[27] Eradication of established tumors by CD8+ T cell adoptive immunotherapy [J].

Hanson, HL ;

Donermeyer, DL ;

Ikeda, H ;

White, JM ;

Shankaran, V ;

Old, LJ ;

Shiku, H ;

Schreiber, RD ;

Allen, PM .

IMMUNITY, 2000, 13 (02) :265-276

[28] Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma [J].

He, Gaixia ;

Zhang, Henghui ;

Zhou, Jinxue ;

Wang, Beibei ;

Chen, Yanhui ;

Kong, Yaxian ;

Xie, Xingwang ;

Wang, Xueyan ;

Fei, Ran ;

Wei, Lai ;

Chen, Hongsong ;

Zeng, Hui .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2015, 34

[29] Conformal Radiation Therapy or Stereotactic Body Radiation Therapy: Institutional Experience in the Management of Colorectal Liver Metastases by Radiation Therapy [J].

He, Zemin ;

Chen, Gang ;

Ouyang, Bo ;

Zhang, Haoyue ;

Chen, Hui ;

Wang, Yehuang ;

Yan, Shushan ;

Pan, Wei .

TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2018, 17

[30] Improved Survival with Ipilimumab in Patients with Metastatic Melanoma [J].

Hodi, F. Stephen ;

O'Day, Steven J. ;

McDermott, David F. ;

Weber, Robert W. ;

Sosman, Jeffrey A. ;

Haanen, John B. ;

Gonzalez, Rene ;

Robert, Caroline ;

Schadendorf, Dirk ;

Hassel, Jessica C. ;

Akerley, Wallace ;

van den Eertwegh, Alfons J. M. ;

Lutzky, Jose ;

Lorigan, Paul ;

Vaubel, Julia M. ;

Linette, Gerald P. ;

Hogg, David ;

Ottensmeier, Christian H. ;

Lebbe, Celeste ;

Peschel, Christian ;

Quirt, Ian ;

Clark, Joseph I. ;

Wolchok, Jedd D. ;

Weber, Jeffrey S. ;

Tian, Jason ;

Yellin, Michael J. ;

Nichol, Geoffrey M. ;

Hoos, Axel ;

Urba, Walter J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (08) :711-723

← 1 2 3 4 5 6 7 8 →