Investigation of GSTM1 and GSTT1 null genotypes as risk factors for Bronchial asthma in a population of central Bulgaria

被引：0

作者：

Dimov, D. ^{[1
]}

Tacheva, T. ^{[2
]}

Ilieva, V ^{[1
]}

Koychev, A. ^{[1
]}

Prakova, G. ^{[1
]}

Andreev, Z. ^{[1
]}

Kurzawski, M. ^{[3
]}

Dimitrov, V ^{[4
]}

Drozdzik, M. ^{[3
]}

Vlaykova, T. ^{[1
]}

机构：

[1] Trakia Univ, Fac Med, Dept Internal Med, Stara Zagora, Bulgaria

[2] Trakia Univ, Fac Med, Dept Chem & Biochem, Stara Zagora, Bulgaria

[3] Pomeranian Med Univ, Dept Expt & Clin Pharmacol, Szczecin, Poland

[4] Med Univ, Clin Ctr Allergol, Sofia, Bulgaria

来源：

ALLERGY, ASTHMA & IMMUNOPHYSIOLOGY: FROM BASIC SCIENCE TO CLINICAL MANAGEMENT | 2013年

关键词：

Bronchial asthma; GSTM1; GSTT1; null polymorphisms; genetic predisposition; GLUTATHIONE; GSTP1; SUSCEPTIBILITY; POLYMORPHISM; METAANALYSIS; GENE; P1; M1;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In the present study we aimed to explore the possible role of the null polymorphisms in two genes of xenobiotic-metabolizing enzymes, GSTM1 and GSTT1 as predisposing factors for Bronchial asthma in a population of central Bulgaria. A statistically significant prevalence of the null GSTM1 genotype (0.55) was observed in asthmatics compared to the control individuals (0.38, p=0.041), which determined 2.01-fold higher risk for Bronchial asthma (OR=2.01, 95% CI, 1.03-3.92). Moreover, patients with GSTM1 null genotype had higher relative risk to develop the disease before 35 years of old (RR=2.31, 95% CI, 1.10-5.14). Regarding the GSTT1 null polymorphism, there was no significant difference of genotype distributions between cases and controls (p=0.323). In conclusion, our current results suggest that the inherited absence of GST-mu, but not GST-theta, due to the homozygous null genotype, appeared to be a low penetrance susceptibility factor for Bronchial asthma and may determine an early onset of the disease.

引用

页码：17 / 20

页数：4

共 15 条

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