Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

被引：28

作者：

Jiang, Shibo ^{[1
,2
,3
]}

Lu, Lu ^{[1
,2
]}

Liu, Qi ^{[1
,2
,4
]}

Xu, Wei ^{[1
,2
]}

Du, Lanying ^{[3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, MOE MOH Key Lab Med Mol Virol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Med Microbiol, Shanghai 200032, Peoples R China

[3] Lindsley F Kimball Res Inst, New York Blood Ctr, New York, NY 10065 USA

[4] Dali Univ, Sch Basic Med, Dept Med Microbiol & Immunol, Dali 671000, Peoples R China

来源：

EMERGING MICROBES & INFECTIONS | 2012年 / 1卷

关键词：

Hendra virus; influenza virus; Nipah virus; receptor-binding domain; SARS-CoV; spike protein; vaccine; virus;

D O I：

10.1038/emi.2012.1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A number of emerging and re-emerging viruses have caused epidemics or pandemics of infectious diseases leading to major devastations throughout human history. Therefore, developing effective and safe vaccines against these viruses is clearly important for the protection of at-risk populations. Our previous studies have shown that the receptor-binding domain (RBD) in the spike protein of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is a key target for the development of SARS vaccines. In this review, we highlight some key advances in the development of antiviral vaccines targeting the RBDs of spike proteins of emerging and re-emerging viruses, using SARS-CoV, influenza virus, Hendra virus (HeV) and Nipah virus (NiV) as examples.

引用

页数：8

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